Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity
Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity
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DOI：
10.1016/j.psyneuen.2007.10.012
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发表时间：
2008-02-01
影响因子：
3.7
通讯作者：
Akil, Huda
中科院分区：
文献类型：
--
作者：
Clinton, Sarah;Miller, Sue;Akil, Huda
在出生前或出生后早期暴露于压力会显著影响成年人的行为和神经内分泌功能。我们最近开始选择性地繁殖Sprague-Dawley大鼠的高（高反应，HR）和低（低反应，LR）新奇寻求行为，这一特征预测了各种情绪反应的差异，包括神经内分泌应激反应的差异，恐惧和焦虑样行为，侵略性和自我管理滥用药物的倾向。我们评估了遗传-早期环境的相互作用，暴露HR和LR繁殖的动物产前应激（PS）从怀孕第3-20天，假设PS暴露会不同地影响HR与LR的行为和神经内分泌反应。我们评估了新奇诱导的运动，焦虑样行为，和皮质酮应激反应在断奶（25日龄）和成年HR-LR强调和控制配偶。暴露于PS并没有改变HR-LR运动的差异，但确实影响焦虑样行为，特别是在LR动物。令人惊讶的是，暴露于PS的LR动物表现出比LR对照更少的焦虑。HR大鼠没有受到PS的影响，压力组和对照组都表现出低水平的焦虑。PS差异影响年轻与成年HR-LR动物的神经内分泌应激反应，导致LR幼鼠的皮质酮反应夸张相比，LR控制，而HR幼鼠不受影响。相比之下，暴露于PS在FIR成年动物中产生了夸大的应激反应，与HR对照组相比，白色LR动物没有受到显著影响。这些发现强调了遗传易感性如何影响个人对早期生活压力源的反应，此外，还表明早期生活压力史可能会在生命的不同阶段对生物体产生不同的影响。未来的工作与探索神经机制的基础上不同的行为和神经内分泌后果的PS在HR与LR动物。(c)2007爱思唯尔有限公司版权所有。
Exposure to stress during prenatal or early postnatal life can dramatically impact adult behavior and neuroendocrine function. We recently began to selectively breed Sprague-Dawley rats for high (high responder, HR) and low (low responder, LR) novelty-seeking behavior, a trait that predicts a variety of differences in emotional reactivity, including differences in neuroendocrine stress response, fear- and anxiety-like behavior, aggression, and propensity to self-administer drugs of abuse. We evaluated genetic-early environment interactions by exposing HR- and LR-bred animals to prenatal stress (PS) from pregnancy day 3-20, hypothesizing that PS exposure would differentially impact HR versus LR behavior and neuroendocrine reactivity. We evaluated novelty-induced locomotion, anxiety-like behavior, and corticosterone stress response in weanling (25-day-old) and adult HR-LR stressed and control mates. Exposure to PS did not alter HR-LR differences in locomotion, but did impact anxiety-like behavior, specifically in LR animals. Surprisingly, LR animals exposed to PS exhibited less anxiety than LR controls. HR rats were not affected by PS, with both stress and control groups showing low levels of anxiety. PS differentially impacted neuroendocrine stress reactivity in young versus adult HR-LR animals, leading to an exaggerated corticosterone response in LR pups compared to LR controls, while HRs pups were unaffected. In contrast, exposure to PS produced an exaggerated stress response in FIR adults, compared to HR controls, white LR animals were not significantly affected. These findings highlight how genetic predisposition may shape individual's response to early life stressors, and furthermore, show that a history of early life stress may differentially impact an organism at different points in life. Future work with explore neural mechanisms which underlie the different behavioral and neuroendocrine consequences of PS in HR versus LR animals. (c) 2007 Elsevier Ltd. All rights reserved.