Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization
Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization
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DOI：
10.1126/science.1066642
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发表时间：
2002-01-25
期刊：
影响因子：
56.9
通讯作者：
Hobert, O
中科院分区：
文献类型：
--
作者：
Aurelio, O;Hall, DH;Hobert, O
在发育过程中，神经元沿着沿着确定的路线将轴突延伸到特定的靶细胞。我们发现，额外的机制，确保轴突保持其正确的定位在定义的轴突束。在轴突生长和靶识别终止后，秀丽隐杆线虫腹神经索（VNC）中的轴突需要特定VNC神经元PVT的存在，以维持它们在VNC的左束和右束中的正确定位。PVT可能通过由zig基因编码的2-免疫球蛋白（IG）结构域蛋白的时间上严格控制的分泌来发挥其稳定功能。专门的轴突维护机制可广泛用于确保功能性神经元回路的保存。
During development, neurons extend axons along defined routes to specific target cells. We show that additional mechanisms ensure that axons maintain their correct positioning in defined axonal tracts. After termination of axonal outgrowth and target recognition, axons in the ventral nerve cord (VNC) of Caenorhabditis elegans require the presence of a specific VNC neuron, PVT, to maintain their correct positioning in the left and right fascicles of the VNC. PVT may exert its stabilizing function by the temporally tightly controlled secretion of 2-immunoglobulin (Ig)-domain proteins encoded by the zig genes. Dedicated axon maintenance mechanisms may be widely used to ensure the preservation of functional neuronal circuitries.