Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study
Transfer of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) From Contaminated Feed Into Milk and Meat of Sheep: Pilot Study
复制标题
DOI：
10.1007/s00244-012-9759-2
复制
发表时间：
2012-08-01
影响因子：
4
通讯作者：
Lahrssen-Wiederholt, Monika
中科院分区：
文献类型：
--
作者：
Kowalczyk, Janine;Ehlers, Susan;Lahrssen-Wiederholt, Monika
对产奶绵羊进行了一项试点研究，以生成关于全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）从饲料转移到动物源食品的第一批数据。在德国的下萨克森的农田上种植玉米青贮饲料，由于2006年的非法废物处置，农田被全氟烷基酸（PFAA）污染。在21天的时间里，两只绵羊通过受PFAA污染的玉米青贮饲料暴露于PFOS（分别为1.16和1.45微克/公斤体重[bw]/天）和PFOA（0.43和0.53微克/公斤体重/天）。在喂食全氟辛烷磺酸期间，绵羊1和绵羊2血浆中的全氟辛烷磺酸浓度持续增加，最高浓度分别为103微克/升和240微克/升。全氟辛酸血浆浓度仍然很低（绵羊1 = 3.3 +/- A 2.2 μ g/L;绵羊2 = 15.6 +/- A 8.3 μ g/L）。数据表明，尿液排泄是全氟辛酸的主要清除途径（绵羊1 = 51%;绵羊2 = 55%），而通过尿液排泄的全氟辛烷磺酸无法量化。粪便中的全氟辛烷磺酸排泄量最高（4%至5%）。通过牛奶排泄的全氟辛烷磺酸水平也高于全氟辛酸。在21天的时间里，计算出全氟辛烷磺酸转移到牛奶中的总量为千分之二。总体而言，全氟辛烷磺酸的总排泄量明显低于全氟辛酸（全氟辛烷磺酸6%;全氟辛酸53%至56%）。绵羊1和绵羊2的全氟辛烷磺酸水平在肝脏中最高（分别为885和1，172微克/千克湿重），在肌肉组织中最低（分别为24.4和35.1微克/千克湿重）。绵羊2肌肉组织中的全氟辛酸水平较低（0.23微克/千克湿重），绵羊1在无全氟辛酸喂养期后检测不到。在绵羊3（对照组）的肝脏（1.5微克/千克湿重）和肾脏（0.3微克/千克湿重）中检测到了轻微的全氟辛烷磺酸本底含量。
A pilot study was performed with dairy sheep to generate the first data on the transfer of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from feed into food of animal origin. Corn silage was cultivated on cropland in Lower Saxony in Germany where, as a result of illegal waste disposal in 2006, farmland was contaminated with perfluorinated alkylacids (PFAAs). Two sheep were exposed by way of PFAA-contaminated corn silage to PFOS (1.16 and 1.45 mu g/kg body weight [bw]/d, respectively) and PFOA (0.43 and 0.53 mu g/kg bw/d) during a period of 21 days. During the PFAA-feeding period, PFOS levels in plasma increased continuously to maximum concentration of 103 and 240 mu g/L for sheep 1 and sheep 2, respectively. The PFOA plasma concentration remained low (sheep 1 = 3.3 +/- A 2.2 mu g/L; sheep 2 = 15.6 +/- A 8.3 mu g/L). Data indicate that urinary excretion is the primary clearance route for PFOA (sheep 1 = 51 %; sheep 2 = 55 %), whereas PFOS excretion by way of urine could not be quantified. The highest PFOS excretion (4 to 5 %) was detected in faeces. PFOS was also excreted at higher levels than PFOA by way of milk. During a period of 21 days, a total PFOS transfer into milk a parts per thousand currency sign2 % was calculated. Overall, total excretion of PFOS was significantly lower compared with that of PFOA (PFOS 6 %; PFOA 53 to 56 %). PFOS levels in sheep 1 and sheep 2 were highest in liver (885 and 1,172 mu g/kg weight wet [ww], respectively) and lowest in muscle tissue (24.4 and 35.1 mu g/kg ww, respectively). PFOA levels in muscle tissue were low for sheep 2 (0.23 mu g/kg ww) and not detectable after the PFAA-free feeding period in sheep 1. A slight background load of PFOS in liver (1.5 mu g/kg ww) and kidney (0.3 mu g/kg ww) was detected in sheep 3 (control).