Antigen receptor allelic exclusion: an update and reappraisal.
Antigen receptor allelic exclusion: an update and reappraisal.
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DOI：
10.4049/jimmunol.1001158
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发表时间：
2010-10-01
期刊：
影响因子：
--
通讯作者：
Bassing CH
中科院分区：
文献类型：
--
作者：
Brady BL;Steinel NC;Bassing CH
Most lymphocytes express cell surface antigen receptor chains from single alleles of distinct immunoglobulin (Ig) or T-cell receptor (TCR) loci. Since the identification of antigen receptor allelic exclusion, the importance of this process and the precise molecular mechanisms by which it is achieved have remained enigmatic. This brief review summarizes current knowledge of the extent to which Ig and TCR loci are subject to allelic exclusion. Recent progress in studying and defining mechanistic steps and molecules that may control the mono-allelic initiation and subsequent inhibition of V-to-(D)-J recombination is outlined using the mouse TCRβ locus as a model with frequent comparisons to the mouse IgH and Igκ loci. Potential consequences of defects in mechanisms that control antigen receptor allelic exclusion and a reappraisal of the physiologic relevance of this immunologic process also are discussed.
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DOI：
10.1084/jem.20061918
发表时间：
2007-01-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
64.8
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通讯作者：
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