Zonulin as marker of pregnancy induced hypertension: a case control study
Zonulin as marker of pregnancy induced hypertension: a case control study
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DOI：
10.1186/s40885-020-00139-x
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发表时间：
2020-04-15
影响因子：
4.2
通讯作者：
Yeboah, Francis Agyemang
中科院分区：
文献类型：
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作者：
Bawah, Ahmed Tijani;Tornyi, Henry;Yeboah, Francis Agyemang
背景：Zonlin与许多代谢紊乱有关，包括高血压和肥胖症。然而，有关zonlin在妊娠高血压综合征(PIH)包括子痫前期(PE)和妊娠高血压综合征(GH)中的作用的研究还很少。因此，这项研究的目的是找出这种调节妊高征女性紧密连接的生化标志物的水平。方法选择88例妊高征组和60例年龄、体重指数(BMI)相匹配的健康孕妇作为对照。比较两组孕妇孕11~13周和孕20周后的血压、体重指数(BMI)、血清锌蛋白水平和血脂水平。两组均数比较采用学生t检验。采用皮尔逊相关分析进行相关分析，采用二元Logistic回归分析与妊高征发病相关的因素。结果妊高征组血清带状蛋白水平显著高于正常妊娠对照组(P<0.0001)，并与妊高征组呈显著正相关(OR=1.805；CI1.139~1.275；P<；0.0001)。然而，妊娠早期的血脂与妊高征间的关联很弱。结论带状蛋白与妊高征发病密切相关，妊娠早期即可出现肠道通透性改变，可能参与了妊高征发病机制。
Background Zonulin has been implicated in many metabolic disorders including hypertension and obesity. However, there is insufficient information about the involvement of zonulin in pregnancy induced hypertension (PIH) which comprises preeclampsia (PE) and gestational hypertension (GH). This study was therefore aimed at finding the level of this biochemical marker of regulation of tight junctions among women with PIH. Methods A total of 88 women with PIH and 60 age and body mass index (BMI) matched healthy pregnant women controls were enrolled. Blood pressure at 11-13 weeks and after 20 weeks of gestation, body mass index (BMI) in addition to serum Zonulin levels and lipid profile were compared between the groups. Student's t-test was used for comparisons of the mean between the two groups. Correlation analyses were performed using Pearson's correlation and binary logistic regression was used to evaluate the factors associated with PIH. Results Zonulin level was significantly higher in the participants with PIH as compared to the normal pregnant controls 56.81 +/- 7.72 ng/ml vs 40.4 +/- 8.60 ng/ml p < 0.0001 and had strong positive correlation with PIH (OR = 1.805; CI1.139-1.275; p < 0.0001). However, the association between first trimester lipids and PIH was weak. Conclusion The results showed a strong positive correlation between zonulin and PIH, thus changes in intestinal permeability occur in early stages of pregnancy and may be involved in the pathogenesis of PIH.