Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums.
Micromixing Enables Chemoselective Reactions of Difunctional Electrophiles with Functional Aryllithiums.
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微混合使双官能亲电子试剂与官能芳基锂发生化学选择性反应。
DOI：
10.1039/c7re00142h
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
J.
中科院分区：
文献类型：
--
作者：
Nagaki;A.; Ishiuchi;S.; Imai;K.; Sasatsuki;K.; Nakahara;Y.; Yoshida;J.
利用配备微混合器的流动微反应器系统，在不保护官能团的情况下，成功地生成了高度不稳定的功能芳基硫化物，然后与双功能亲电体进行化学选择性反应。极快的微混合导致了高的化学选择性。
Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Extremely fast micromixing is responsible for high chemoselectivity.