Interaction of nanosized copolymer networks with oppositely charged amphiphilic molecules
Interaction of nanosized copolymer networks with oppositely charged amphiphilic molecules
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DOI：
10.1021/nl0100365
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发表时间：
2001-10-01
期刊：
影响因子：
10.8
通讯作者：
Kabanov, AV
中科院分区：
文献类型：
--
作者：
Bronich, TK;Vinogradov, SV;Kabanov, AV
通过交联亲水性非离子和阳离子聚合物聚（环氧乙烷）-cl-聚乙烯亚胺与阴离子表面活性剂反应，合成了一类新型纳米复合材料。从聚乙烯亚胺-表面活性剂复合物的疏水域的形成导致网络崩溃，表现在从约100 μ m的粒径减小。300 nm至约50 nm。由于它们的交联结构，与由接枝共聚物、聚（环氧乙烷）-g-聚乙烯亚胺和表面活性剂形成的复合物相比，基于聚（环氧乙烷）-cl-聚乙烯亚胺的复合物对环境特性（例如pH和盐浓度）的变化更具抗性。难溶性的生物活性分子，视黄酸和吲哚美辛，固定在网络复合物形成稳定的水分散体。已经证明了药物从网络分散体中的释放。这些材料在药物递送应用中作为载体是潜在有用的。
A new class of nanocomposite materials is synthesized by reacting nanoscale networks of cross-linked hydrophilic nonionic and cationic polymers, poly(ethylene oxide)-cl-polyethyleneimine, with anionic surfactants. Formation of hydrophobic domains from polyethyleneimine-surfactant complexes leads to a network collapse exhibited in a decrease in the particle size from ca. 300 nm to ca. 50 nm. Due to their cross-linked architecture, the poly(ethylene oxide)-cl-polyethyleneimine-based complexes are more resistant to the changes in the environmental characteristics, such as pH and salt concentration, compared to complexes formed by a graft copolymer, poly(ethylene oxide)-g-polyethyleneimine and surfactants. Poorly soluble biologically active molecules, retinoic acid and indomethacin, were immobilized in the network complexes forming stable aqueous dispersions. The release of the drug from the network dispersion has been demonstrated. These materials are potentially useful as carriers in pharmaceutical drug delivery applications.