Progressive multifocal leukoencephalopathy in multiple myeloma associated with daratumumab, lenalidomide, and dexamethasone
Progressive multifocal leukoencephalopathy in multiple myeloma associated with daratumumab, lenalidomide, and dexamethasone
复制标题
与达雷妥尤单抗、来那度胺和地塞米松相关的多发性骨髓瘤进行性多灶性白质脑病
DOI：
10.1111/ncn3.12586
复制
发表时间：
2022
影响因子：
0.4
通讯作者：
Matsukawa Noriyuki
中科院分区：
文献类型：
--
作者：
Seko Kento;Uchida Yuto;Kanamori Takashi;Sakurai Keita;Usami Toshihiko;Kuno Tomoyuki;Takada Koji;Nakamichi Kazuo;Matsukawa Noriyuki
进行性多灶性白质脑病是一种罕见但致命的中枢神经系统脱髓鞘疾病，伴有JC病毒的再激活。在此，我们描述了一例进行性多灶性白质脑病与达拉单抗、来那度胺和地塞米松治疗多发性骨髓瘤的治疗方案相关。一名69岁多发性骨髓瘤患者在接受7个疗程的治疗后，因进行性认知功能障碍而住进神经系统护理病房。CD4+T细胞计数190个/μL。扩散加权磁共振成像显示结节扩散限制在额叶和顶叶。在脑脊液中JC病毒DNA聚合酶链反应试验阳性后，他被诊断为进行性多灶性白质脑病。停止多发性骨髓瘤治疗后，患者的认知和磁共振成像结果在3个月内有所改善。我们应该认识到，在接受这种治疗方案的患者中，这种潜在的致命并发症。
Progressive multifocal leukoencephalopathy is a rare but fatal demyelinating disease of the central nervous system with reactivation of JC virus. Herein, we describe a case of progressive multifocal leukoencephalopathy associated with a therapeutic regimen of daratumumab, lenalidomide, and dexamethasone for multiple myeloma. A 69‐year‐old man with multiple myeloma was admitted to the neurological care unit due to progressive cognitive dysfunction after seven cycles of the regimen. His CD4+T cell count was 190 cells/μL. Diffusion‐weighted magnetic resonance imaging revealed nodular diffusion restrictions in the frontal and parietal lobes. He was diagnosed with progressive multifocal leukoencephalopathy following a positive polymerase chain reaction test for JC virus DNA in the cerebrospinal fluid. After cessation of multiple myeloma treatment, his cognition and magnetic resonance imaging findings improved within 3 months. We should recognize this potentially fatal complication in patients receiving this regimen.
多发性骨髓瘤达雷妥尤单抗治疗后出现进行性多灶性白质脑病：病例报告
DOI：
10.1016/j.jns.2021.118916
发表时间：
2021
期刊：
Journal of Neurological Sciences
影响因子：
--
作者：
N. Caracciolo;L. Clemente;P. Galizia;S. Cesa;L. Prosperini;V. Cozzolino;C. Gasperini;C. Tortorella
通讯作者：
C. Tortorella