Ionic Dimethacrylates for Antimicrobial and Remineralizing Dental Composites.
Ionic Dimethacrylates for Antimicrobial and Remineralizing Dental Composites.
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发表时间：
2018-05
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通讯作者：
D. Bienek;Stanislav A. Frukhtbeyn;A. Giuseppetti;U. Okeke;R. M. Pires;J. Antonucci;D. Škrtić
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作者：
D. Bienek;Stanislav A. Frukhtbeyn;A. Giuseppetti;U. Okeke;R. M. Pires;J. Antonucci;D. Škrtić
通过亲核取代反应合成了两种离子二甲丙烯酸酯（IDMA1和IDMA2），用于多功能、抗菌和再矿化牙科树脂和复合材料。以乙醇-乙醚-己烷为溶剂体系，采用多步萃取法纯化粗idma。用核磁共振和质谱对其结构进行了验证。水接触角测量值（63.2-65.5）0)表明，idma不影响二甲基丙烯酸乙酯（UDMA）基共聚物的润湿性（平均接触角为（60.8±5.1）0）。乙烯基转化率从88.1%（无idma控制）提高到93.0% （IDMA2系列）。共聚物的抗折强度（FS）从94.8 MPa（对照）降至68.9-71.8 MPa （IDMA对照），与单体类型和/或浓度无关。FS的减少不应使idma丧失作为多功能恢复性抗菌剂的资格。在超过固化共聚物和/或复合材料中未反应单体的预期浸出率的浓度下进行测试，idma对成纤维细胞的生存能力和/或代谢活性没有有害影响。通过钙磷酸盐离子释放动力学实验，证实了非晶态磷酸钙IDMA/UDMA复合材料的再矿化潜力。本研究的结果保证了对IDMA树脂和复合材料进行深入的生物学、物理化学、机械和抗菌评估，以确定适合临床试验的原型。
Two ionic dimethacrylates (IDMA1 and IDMA2) intended for utilization in multifunctional, antibacterial and remineralizing dental resins and composites were synthesized by nucleophilic substitution reactions. Crude IDMAs were purified by multi-step extraction from ethanol-diethyl ether-hexane solvent system. Their structures were validated by nuclear magnetic resonance and mass spectrometry. As evidenced by the water contact angle measurements ((63.2-65.5)0), IDMAs did not affect the wettability of urethane dimethacrylate (UDMA)- based copolymers (average contact angle ((60.8±5.1)0).The attained degrees of vinyl conversion increased from 88.1% (no-IDMA control) up to 93.0% (IDMA2 series). Flexural strength (FS) of copolymers was reduced from 94.8 MPa (control) to (68.9-71.8) MPa (IDMA counterparts) independent of monomer type and/or its concentration. This reduction in FS should not disqualify IDMAs from consideration as viable antibacterial agents in multifunctional restoratives. Tested at concentrations exceeding the expected leachability of unreacted monomers from cured copolymers and/or composites, IDMAs had no deleterious effect on viability and/or metabolic activity of fibroblasts. The remineralization potential of amorphous calcium phosphate IDMA/UDMA composites was confirmed by calcium and phosphate ion release kinetic experiments. Results of this study warrant in-depth biological, physicochemical, mechanical and antibacterial assessments of IDMA resins and composites to identify prototype(s) suitable for clinical testing.