Synthesis of glucose-sensitive self-assembled films and their application in controlled drug delivery
Synthesis of glucose-sensitive self-assembled films and their application in controlled drug delivery
复制标题
葡萄糖敏感自组装薄膜的合成及其在控制药物递送中的应用
DOI：
10.1016/j.polymer.2009.07.001
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发表时间：
2009-08
期刊：
影响因子：
4.6
通讯作者：
Guan, Ying
中科院分区：
文献类型：
--
作者：
Zhang, Yongjun;Ding, Zhibo;Zhu, X. X.;Guan, Ying
Hydrogen-bonded layer-by-layer assembled films from poly(vinyl pyrrolidone) and poly(acrylic acid) were crosslinked with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and ethylenediamine, and modified with 3-aminophenylboronic acid and isopropylamine simultaneously. The resultant films present pH- and thermosensitive swelling behaviors. Furthermore, the swelling of the films is enhanced when saccharides, such as glucose or fructose, is present in the solution. Alizarin Red S (ARS) was used as a model drug to study the drug release behavior of the films. The loading amount of ARS increases with increasing ARS concentration, which binds covalently with the phenylboronic acid groups in the film. The release of ARS is faster in the presence of glucose, which competes with ARS for binding sites in the film. The novel multistimuli-sensitive films may find applications in self-regulated insulin delivery.
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影响因子：
9.9
作者：
M. Rusu;D. Kuckling;H. Möhwald;M. Schönhoff
通讯作者：
M. Rusu;D. Kuckling;H. Möhwald;M. Schönhoff
影响因子：
3.9
作者：
De Geest, Bruno G.;Jonas, Alain M.;De Smedt, Stefaan C.
通讯作者：
De Smedt, Stefaan C.
影响因子：
2.7
作者：
Steitz, R;Leiner, V;Von Klitzing, R
通讯作者：
Von Klitzing, R
影响因子：
4.6
作者：
P. Bertrand;A. Jonas;A. Laschewsky;R. Legras
通讯作者：
P. Bertrand;A. Jonas;A. Laschewsky;R. Legras
影响因子：
2.5
作者：
Glinel, K;Sukhorukov, GB;Tauer, K
通讯作者：
Tauer, K