Melatonin in humans: It's about time
Melatonin in humans: It's about time
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DOI：
10.1111/j.1365-2826.2005.01333.x
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发表时间：
2005-08-01
影响因子：
3.2
通讯作者：
Arendt, J
中科院分区：
文献类型：
--
作者：
Arendt, J
褪黑激素通过其有节奏的分泌来发出夜间信号。它的测量提供了内部生物钟计时的最佳指标。褪黑激素治疗会引起嗜睡，并在“生物日”(即褪黑激素内源性分泌最少的时候)降低体温，并作为“生物钟”来改变生物钟的时间。它已经成功地用于治疗人类的生物节律紊乱。
Melatonin signals night time by its rhythmic profile of secretion. Its measurement provides the best indicator of internal circadian clock timing. Treatment with melatonin induces sleepiness and lowers body temperature during 'biological day' (i.e. when its endogenous secretion is minimal) and it acts as a 'chronobiotic' to change the timing of the circadian clock. It has been used successfully to treat disorders of biological rhythms in humans.