The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese
The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese
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DOI：
10.1016/j.physbeh.2014.02.053
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发表时间：
2014-04-22
影响因子：
2.9
通讯作者：
Miyachi, Motohiko
中科院分区：
文献类型：
--
作者：
Murakami, Haruka;Iemitsu, Motoyuki;Miyachi, Motohiko
体力活动（PA）与降低全因死亡率的风险以及心血管疾病和中风的患病率有关。然而，总人口中有很大一部分可能不够活跃。PA水平受遗传因素的影响，我们研究了瘦素受体（LEPR）基因Q223 R多态性是否与PA水平相关。共有556名24-65岁的日本成年人参加了这项横断面研究。三轴加速度计客观评价PA的持续时间和强度。采用TaqMan方法检测Q223 R多态性。Q223 R多态性分布为QQ 0.7%，QR 22.6%，RR 76.6%。以年龄和性别为协变量，采用Q显性遗传模型，对LEPR基因型与PA水平的关系进行协方差分析。LEPR基因型与光PA时间和不活动时间之间存在显著性差异。具有RR基因型的受试者在轻度PA中的时间显著缩短（RR基因型：559.4 +/- 102.9分钟/天，QQ/QR基因型：579.9 +/- 103.1分钟/天）和更长的非活动时间RR基因型为815.5 ± 107.5min/d，QQ/QR基因型为792.3 ± 107.7min/d，与QQ/QR基因型相比差异有统计学意义（P < 0.05）。在中度或剧烈PA中花费的时间没有这种差异。这些结果表明，PA水平的变化，特别是自发PA在人类，部分是由LEPR基因的多样性。(C)2014作者爱思唯尔公司出版
Physical activity (PA) is associated with reductions in the risk of all-cause mortality and in the prevalence of cardiovascular disease and stroke. Nevertheless, a large proportion of the general population may not be sufficiently active. PA level has been reported to be influenced by genetic factors, and we investigated whether Q223R polymorphism in the leptin receptor (LEPR) gene was associated with PA level. A total of 556 Japanese adults aged 24-65 years old participated in this cross-sectional study. The duration and intensity of PA were objectively evaluated by triaxial accelerometry. Q223R polymorphism was determined by the TaqMan method. The distribution of Q223R polymorphism was: QQ 0.7%, QR 22.6%, and RR 76.6%. The relation between the LEPR genotype and PA level was analyzed by ANCOVA with age and sex as covariates in the Q dominant genetic model. There were significant differences between LEPR genotypes and the time spent in light PA or inactive time. The subjects with RR genotype showed significantly shorter time spent in light PA (RR genotype: 559.4 +/- 102.9 min/day, QQ/QR genotype: 579.9 +/- 103.1 min/day) and longer inactive time (RR genotype: 815.5 +/- 107.5 min/day, QQ/QR genotype: 792.3 +/- 107.7 min/day) than the subjects with QQ/QR genotype (P < 0.05). There were no such differences in the time spent in moderate or vigorous PA. These results suggest that the variety of PA level, especially spontaneous PA in humans, is partly caused by diversity in the LEPR gene. (C) 2014 The Authors. Published by Elsevier Inc.