An immunohistochemical evaluation of BMP-2,-4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva
An immunohistochemical evaluation of BMP-2,-4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva
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DOI：
10.1016/j.oraloncology.2006.03.017
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发表时间：
2007-04-01
期刊：
影响因子：
4.8
通讯作者：
Sasaki, Akira
中科院分区：
文献类型：
--
作者：
Ono, Akiko;Tsukamoto, Goichi;Sasaki, Akira
本研究检测了骨化性纤维瘤（OF, n = 5）和外周骨水泥骨化性纤维瘤（PCOF, n = 7）的组织学差异。采用骨形态发生蛋白(BMP)-2和-4、骨桥蛋白（OPN）、骨钙素（OCN）和增殖细胞核抗原（PCNA）进行免疫组化检查。对牙周组织中的氧化塔坦纤维进行染色以确定肿瘤细胞的来源。与PCOFs相比，许多OFs对BMP-2、-4和OPN表现出较高的免疫组化反应。OFs的PCNA指数（IP）显著高于PCOFs。所有PCOFs均高表达氧talan纤维。只有两种OFs表现出少量的氧talan纤维。这些结果表明，PCOF形成硬组织的能力很小，似乎是一种反应性病变。氧talan纤维的表达表明of不仅起源于牙周组织。(c) 2006 Elsevier Ltd.版权所有。
The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytatan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontat tissue. (c) 2006 Elsevier Ltd. All rights reserved.