Distribution of distant metastases from newly diagnosed non-small cell lung cancer
Distribution of distant metastases from newly diagnosed non-small cell lung cancer
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DOI：
10.1016/0003-4975(96)00220-2
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发表时间：
1996-07-01
影响因子：
4.6
通讯作者：
Orringer, MB
中科院分区：
文献类型：
--
作者：
Quint, LE;Tummala, S;Orringer, MB
背景。本研究的目的是确定非小细胞肺癌患者出现M1病变时的发生率和位置，以帮助设计合适的术前成像算法。1991年至1993年间发现的所有非小细胞肺癌患者均被确定，并对记录进行了回顾。对于M1患者，记录远处转移部位和诊断方法。在确定的345例患者中，276例（79%）患有M0疾病，72例（21%）患有M1疾病。72例患者中有40例（56%）通过胸部或腹部计算机断层扫描（CT）检测到M1疾病。脑、骨、肝和肾上腺是转移性疾病最常见的部位（按降序排列）。脑转移常作为孤立的发现发生，尽管孤立的肝转移并不常见。M1疾病在发病时很常见，经常通过胸部CT检测到。腹部CT相对于胸部CT的增量量非常小，因此，如果做过胸部CT，腹部CT并不是筛查转移瘤的有效方法。
Background. The purpose of our study was to determine the incidence and locations of M1 disease at presentation in patients with non-small cell lung cancer to help design appropriate preoperative imaging algorithms.Methods. All patients with non-small cell lung cancer seen between 1991 and 1993 were identified, and records were reviewed. For patients with M1 disease, the sites of distant metastases and the methods of diagnosis were recorded.Results. Of 345 patients identified, 276 (79%) had M0 disease and 72 (21%) had M1 disease. In 40 of 72 patients (56%), M1 disease was detected via chest or abdominal computed tomography (CT). Brain, bone, liver, and adrenal glands were the most common sites of metastatic disease, in decreasing order. Brain metastases often occurred as an isolated finding, although isolated liver metastases were uncommon.Conclusions. M1 disease was common at presentation, and was often detectable via chest CT. The incremental yield of abdominal CT over chest CT was very small, and therefore abdominal CT is not an effective method of screening for metastases if chest CT has been performed.