The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population.
The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population.
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染色体4q25上的rs6817105多态性与中国汉族人群房颤风险相关
DOI：
10.5152/anatoljcardiol.2015.6542
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发表时间：
2016-09
影响因子：
1.3
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
Fang Z;Liu Y;Ni B;Chen XG;Zhao L;Zhang F
以前的全基因组关联研究（GWAS）已经确定rs6817105-染色体4 q25上的单核苷酸多态性（SNP）-与欧洲血统人群中房颤（AF）的风险相关。我们最近在一个大的日本血统队列中证明了这种关联。我们目前的研究旨在确定中国汉族人群中的这种关联。该病例对照研究包括597例AF病例和996例无AF对照，并使用TaqMan等位基因鉴别试验对rs6817105 SNP进行基因分型。Logistic回归模型计算比值比（OR）和95%置信区间（95%CI）。rs6817105-CC基因型在房颤患者中的分布频率显著高于对照组（p=3.24 ′ 10-32）。在我们的研究中，logistic回归分析显示rs6817105与房颤风险之间存在强相关性。（加性模型：OR=2.22，95%CI=1.89-2.61，p=2.33 <$10 -22;显性模型：OR=2.96，95%CI：2.16-4.07，p=2.03 <$10 -11;隐性模型：OR=2.83，95%CI=2.27-3.54，p=4.00 <$10 -20）。分层分析显示rs6817105与AF风险相关性的年龄亚组之间存在临界统计学差异（p=0.049）。然而，进一步的交互分析表明，rs6817105基因型与年龄之间没有显着的交互作用（p=0.178）。我们的发现表明SNP rs6817105可能与中国汉族人群中房颤的高显著风险相关，但需要更多的大样本量重复研究来证实这一发现。
Previous genome-wide association studies (GWASs) have identified rs6817105—a single nucleotide polymorphism (SNP) on chromosome 4q25—to be associated with the risk of atrial fibrillation (AF) in a European-descent population. We recently demonstrated this association in a large cohort of Japanese ancestry. Our present study was designed to determine this association in the Chinese Han population. This case–control study included 597 AF cases and 996 AF-free controls, and rs6817105 SNPs were genotyped using the TaqMan allelic discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated in logistic regression models. The genotype distribution of rs6817105-CC was significantly more frequent in the AF patients than in the controls (p=3.24´10-32). In our study, logistic regression analysis showed a strong association between rs6817105 and the risk of AF (additive model: OR=2.22, 95%CI=1.89–2.61, p=2.33´10-22; dominant model: OR=2.96, 95% CI: 2.16–4.07, p=2.03´10-11; recessive model: OR=2.83, 95%CI=2.27–3.54, p=4.00´10-20). Stratification analyses showed a borderline statistical difference between subgroups of age for the association of rs6817105 with AF risk (p=0.049). However, further interactive analysis indicated no significant interaction between genotype of rs6817105 and age (p=0.178). Our finding suggested that SNP rs6817105 may be associated with a high significant risk of AF in the Chinese Han population, although more replicative studies of larger sample size are needed to confirm this finding.