Hypnotic residual effects of benzodiazepines with repeated administration.
Hypnotic residual effects of benzodiazepines with repeated administration.
复制标题
重复给药时苯二氮卓类药物的催眠残留作用。
作者：
T. Roehrs;N. Kribbs;F. Zorick;T. Roth
性能指标进行了比较，多次睡眠潜伏期试验（MPEST）作为指标，以评估在重复夜间给药期间苯二氮卓类催眠药的残留作用的耐受性。12名健康、正常睡眠者在重复测量中接受了9个晚上的泮30 mg、替马西泮30 mg和安慰剂，拉丁方设计中有19个晚上的恢复期。与安慰剂相比，两种药物在研究的早期（第1-2晚）和晚期（第8-9晚）改变了睡眠阶段参数。催眠作用，发现这两种药物在早期阶段，但减少了在晚期阶段。受试者在第二天的表现在早期阶段用泮治疗后被破坏，但用替马西泮治疗后没有被破坏。在早期阶段，两种药物均降低了MIPs上的平均睡眠潜伏期。在晚期阶段，泮并没有破坏性能，但仍然影响了二尖瓣。第二天，在晚期阶段，Temazepam对两个指数都没有影响。
Performance measures were compared to the multiple sleep latency test (MSLT) as indices to assess tolerance to the residual effects of benzodiazepine hypnotics during repeated nightly administration. Twelve healthy, normal sleepers received flurazepam 30 mg, temazepam 30 mg, and placebo for nine nights in a repeated measures, Latin-square design with 19 nights of recovery separating the treatments. As compared to placebo, both drugs altered sleep stage parameters in the early (nights 1-2) and late (nights 8-9) phases of the study. Hypnotic effects were found for both drugs in the early phase, but diminished for both in the late phase. The subjects' performance the next day was disrupted following treatment with flurazepam, but not with temazepam, during the early phase. Mean sleep latency on the MSLT was reduced by both drugs during the early phase. During the late phase, flurazepam did not disrupt performance but still affected the MSLT. Temazepam affected neither index the next day during the late phase.