MUSCLE ENERGY-METABOLISM AND NUTRITIONAL-STATUS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE - A P-31 MAGNETIC-RESONANCE STUDY
MUSCLE ENERGY-METABOLISM AND NUTRITIONAL-STATUS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE - A P-31 MAGNETIC-RESONANCE STUDY
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DOI：
10.1164/ajrccm.152.2.7633721
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发表时间：
1995-08-01
影响因子：
24.7
通讯作者：
YAMABAYASHI, H
中科院分区：
文献类型：
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作者：
KUTSUZAWA, T;SHIOYA, S;YAMABAYASHI, H
本文采用P-31核磁共振波谱（P-31- mrs）技术对18例男性慢性阻塞性肺疾病（COPD）患者和15例男性对照组进行运动时营养状况与肌肉能量代谢的关系研究。将患者和对照组进一步分为营养良好（%理想体重，% IBW大于或等于90）和营养不良（% IBW < 90）状态。通过测定PCr/(PCr + Pi) （PCr，磷酸肌酸；Pi，无机磷酸盐）和ATP/(PCr + Pi + ATP)的比值来评估肌肉能量代谢。这项练习包括反复握紧重物。通过将完成的工作除以前臂无脂肪横截面积（使用H-1-MRS计算），将个体瘦肌肉质量的工作率归一化。运动期间的PCr/(PCr + Pi)值与任何对照组或COPD患者的IBW %无关。此外，在营养良好或营养不良的受试者组中，PCr/(PCr + Pi)与标准化工作率无关。然而，在对照组和COPD患者组之间存在相关性。COPD患者标准化工作率的PCr/(PCr + Pi)值始终低于中心受试者。这些发现表明，COPD患者肌肉代谢的改变不受营养状况的影响。
We investigated the relationship between nutritional status and muscle energy metabolism during exercise in 18 male patients with chronic obstructive pulmonary disease (COPD) and 15 male control subjects using P-31 nuclear magnetic resonance spectroscopy (P-31-MRS). The patients and control subjects were further categorized as in either a well-nourished (% ideal body weight, % IBW greater than or equal to 90) or malnourished (% IBW < 90) state. Muscle energy metabolism was evaluated by determining the ratios PCr/(PCr + Pi) (PCr, phosphocreatine; Pi, inorganic phosphate), and ATP/(PCr + Pi + ATP). The exercise consisted of repetitive hand grips performed against a load. The work rate was normalized for the individual's lean muscle mass by dividing work performed by the forearm fat-free cross-sectional area, which was calculated using H-1-MRS. The PCr/(PCr + Pi) values during exercise did not correlate with the % IBW in any of the groups of control subjects or COPD patients. Furthermore, the PCr/(PCr + Pi) did not correlate with the normalized work rate in either the well-nourished or malnourished subject groups. However, there were correlations within the groups of control subjects and COPD patients. The PCr/(PCr + Pi) values for the normalized work rate were consistently lower in the COPD patients than in the central subjects. These findings suggest that the altered muscle metabolism in COPD patients is not affected by their nutritional status.