Some behavioral effects of maternal hypervitaminosis A in rats.
Some behavioral effects of maternal hypervitaminosis A in rats.
复制标题
母体维生素 A 过多症对大鼠的一些行为影响。
DOI：
10.1002/tera.1420100309
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
C. Vorhees
中科院分区：
文献类型：
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作者：
C. Vorhees
Gravid Fischet 大鼠在妊娠第 8-10 天口服 100,000、40,000、25,000 或 10,000 IU/kg/天维生素 A 棕榈酸酯 (VA)。最大的剂量会导致较高的产前和产后死亡率，并导致少数幸存者出现明显的生长迟缓和步态异常。三种较低的剂量没有导致后代死亡率增加、体重没有减少，也没有任何明显的异常。后代在 70-72 天龄时在露天场地进行测试。与生理盐水和未处理的对照相比，暴露于 100,000 IU VA 的受试者表现出活动减退。在 73-77 天时，对后代进行 Y 迷宫回避任务测试。所有实验组都表现出回避和歧视习得的减少，这在 100,000 IU 组中最为明显。
Gravid Fischet rats were given 100,000, 40,000, 25,000, or 10,000 IU/kg/day vitamin A palmitate (VA) orally on days 8–10 of gestation. The largest dosage produced high prenatal and postnatal mortality rates and marked growth retardation and abnormal gait in the few survivors. The three lower dosages produced no increased mortality, no weight reduction, nor any visible abnormalities in the offspring. The off spring were tested at 70–72 days of age in an open field. Those exposed to 100,000 IU VA showed hypoactivity compared with saline and nontreated controls. At 73–77 days of age the offspring were tested in a Y-maze avoidance task. All experimental groups showed decreased avoidance and discrimination acquisition, which was most pronounced in the 100,000 IU group.