BIOLOGICAL VARIATION OF ACUTE-PHASE PROTEINS
BIOLOGICAL VARIATION OF ACUTE-PHASE PROTEINS
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DOI：
10.1177/000456329303000404
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发表时间：
1993-07-01
影响因子：
2.2
通讯作者：
FRASER, CG
中科院分区：
文献类型：
--
作者：
CLARK, GH;FRASER, CG
在20周内，对19例明显健康受试者队列中的血清白蛋白、甲状腺素运载蛋白、α 1-酸性糖蛋白、α 1-抗糜蛋白酶、触珠蛋白、β 2-微球蛋白和C-反应蛋白的分析、受试者内和受试者间变异成分进行了估计。除了血清白蛋白和β 2-微球蛋白需要进行方法学改进外，应能够满足基于生物学变异的理想分析目标。所有的蛋白质显示出显着的个性，怀疑传统的基于人群的参考值作为解释标准的效用。序列结果中变化的显著性所需的关键差异在蛋白质之间存在显著差异，所提供的数据允许生成用于监测个体的客观标准。
The analytical, within-subject and between-subject components of variation were estimated for serum albumin, transthyretin, alpha1-acid glycoprotein, alpha1-antichymotrypsin, haptoglobin, beta2-microglobulin and C-reactive protein in a cohort of 19 apparently healthy subjects over 20 weeks. Desirable analytical goals based on biological variation should be able to be met except for serum albumin and beta2-Microglobulin for which methodological improvement is warranted. All proteins showed marked individuality which casts doubt on the utility of conventional population-based reference values as interpretative criteria. The critical differences required for significance of changes in serial results differ markedly from protein to protein and the data presented allow generation of objective criteria for monitoring individuals.