Evolution of a guarded decoy protease and its receptor in solanaceous plants
Evolution of a guarded decoy protease and its receptor in solanaceous plants
复制标题
DOI：
10.1038/s41467-020-18069-5
复制
发表时间：
2020-09-02
影响因子：
16.6
通讯作者：
van der Hoorn, Renier A. L.
中科院分区：
文献类型：
--
作者：
Kourelis, Jiorgos;Malik, Shivani;van der Hoorn, Renier A. L.
Rcr3是番茄的分泌蛋白酶，其被真菌效应子Avr2（真菌病原体黄枝孢菌（Cladosporium fulvum）的分泌蛋白酶抑制剂）靶向。Avr2-Rcr3复合物被受体样蛋白Cf-2识别，触发过敏性细胞死亡（HR）和抗病性。Avr2还靶向Rcr3 partial Pip1，其不是Avr2识别所需的，但有助于基础抗性。因此，Rcr3在这种相互作用中充当了一个受保护的诱饵，将真菌捕获到识别事件中。在这里，我们表明Rcr3在> 5000万年前（Mya）进化，而Cf-2进化
Rcr3 is a secreted protease of tomato that is targeted by fungal effector Avr2, a secreted protease inhibitor of the fungal pathogen Cladosporium fulvum. The Avr2-Rcr3 complex is recognized by receptor-like protein Cf-2, triggering hypersensitive cell death (HR) and disease resistance. Avr2 also targets Rcr3 paralog Pip1, which is not required for Avr2 recognition but contributes to basal resistance. Thus, Rcr3 acts as a guarded decoy in this interaction, trapping the fungus into a recognition event. Here we show that Rcr3 evolved > 50 million years ago (Mya), whereas Cf-2 evolved