FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries.
FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries.
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DOI：
10.1097/iae.0000000000000586
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Rosen RB
中科院分区：
文献类型：
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作者：
Pinhas A;Dubow M;Shah N;Cheang E;Liu CL;Razeen M;Gan A;Weitz R;Sulai YN;Chui TY;Dubra A;Rosen RB
使用自适应光学扫描光检眼底荧光素血管造影检查非缺血性视网膜中央静脉闭塞（CRVO）的眼睛是否有异常，这可能解释了他们未来闭塞的风险增加。自适应光学扫描光检眼镜荧光素血管造影计算中央凹微血管密度。中心凹无血管区附近未灌注的毛细血管被发现。光谱域光学相干断层扫描、超宽场荧光素血管造影和显微显微镜也进行了检查。对9例非缺血性CRVO和1例非缺血性半CRVO患者的10只眼和3例非缺血性CRVO和1例非缺血性半CRVO患者的4只眼进行成像。90%的正常眼和100%的受影响眼至少有1条毛细血管未灌注，而健康眼的这一比例为31%。眼侧微血管密度（35±3.6 mm−1）显著高于患病眼（25±5.2 mm−1），显著低于健康眼（42±4.2 mm−1）。与健康对照组相比，光谱域光学相干断层扫描厚度无显著差异，而显微镜和2/9超宽视场荧光素血管造影显示双眼异常。自适应光学扫描光检眼镜荧光素血管造影检测到的眼部变化反映了难以用常规成像技术检测到的亚临床病理。这些变化可能有助于阐明非缺血性CRVO的发病机制，并有助于识别未来闭塞风险增加的眼睛。
Eyes fellow to nonischemic central retinal vein occlusion (CRVO) were examined for abnormalities, which might explain their increased risk for future occlusion, using adaptive optics scanning light ophthalmoscope fluorescein angiography. Adaptive optics scanning light ophthalmoscope fluorescein angiography foveal microvascular densities were calculated. Nonperfused capillaries adjacent to the foveal avascular zone were identified. Spectral domain optical coherence tomography, ultrawide field fluorescein angiographies, and microperimetry were also performed. Ten fellow eyes of nine nonischemic CRVO and 1 nonischemic hemi-CRVO subjects and four affected eyes of three nonischemic CRVO and one nonischemic hemi-CRVO subjects were imaged. Ninety percent of fellow eyes and 100% of affected eyes demonstrated at least 1 nonperfused capillary compared with 31% of healthy eyes. Fellow eye microvascular density (35 ± 3.6 mm−1) was significantly higher than that of affected eyes (25 ± 5.2 mm−1) and significantly lower than that of healthy eyes (42 ± 4.2 mm−1). Compared with healthy controls, spectral domain optical coherence tomography thicknesses showed no significant difference, whereas microperimetry and 2/9 ultrawide field fluorescein angiography revealed abnormalities in fellow eyes. Fellow eye changes detectable on adaptive optics scanning light ophthalmoscope fluorescein angiography reflect subclinical pathology difficult to detect using conventional imaging technologies. These changes may help elucidate the pathogenesis of nonischemic CRVO and help identify eyes at increased risk of future occlusion.