Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings.
Relation of Habitual Chocolate Consumption to Arterial Stiffness in a Community-Based Sample: Preliminary Findings.
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基于社区的样本中习惯性巧克力消费与动脉僵硬的关系：初步发现。
DOI：
10.1159/000445876
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Abhayaratna,WalterP
中科院分区：
文献类型：
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作者：
Crichton,GeorginaE;Elias,MerrillF;Alkerwi,Ala'a;Stranges,Saverio;Abhayaratna,WalterP
背景：巧克力和可可的消费已证实对心血管有益。巧克力对动脉僵硬的影响知之甚少，动脉僵硬是亚临床心血管疾病的标志。本研究的目的是调查在调整心血管、生活方式和饮食因素后，巧克力摄入量是否与脉搏波速度(PWV)独立相关。方法：对来自缅因州锡拉丘兹纵向研究(MSLS)的508名社区居民(平均年龄61岁，60%为女性)进行了前瞻性分析。结果：巧克力摄入量与PWV呈显著的非线性关系，从不吃巧克力或很少吃巧克力的人PWV水平最高，每周吃一次巧克力的人PWV水平最低。在对糖尿病、心血管危险因素和饮食变量进行多变量调整后，这种结果模式仍然存在，并且没有减弱(p=0.002)。结论：每周摄入巧克力可能有利于动脉僵硬。需要进一步的研究来探索可能调节习惯性食用巧克力对动脉僵硬的影响的潜在机制。
Background:The consumption of chocolate and cocoa has established cardiovascular benefits. Less is known about the effects of chocolate on arterial stiffness, a marker of subclinical cardiovascular disease. The aim of this study was to investigate whether chocolate intakes are independently associated with pulse wave velocity (PWV), after adjustment for cardiovascular, lifestyle and dietary factors.Methods:Prospective analyses were undertaken on 508 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study (MSLS). Habitual chocolate intakes, measured using a food frequency questionnaire, were related to PWV, measured approximately 5 years later.Results:Chocolate intake was significantly associated with PWV in a non-linear fashion with the highest levels of PWV in those who never or rarely ate chocolate and lowest levels in those who consumed chocolate once a week. This pattern of results remained and was not attenuated after multivariate adjustment for diabetes, cardiovascular risk factors and dietary variables (p = 0.002).Conclusions:Weekly chocolate intake may be of benefit to arterial stiffness. Further studies are needed to explore the underlying mechanisms that may mediate the observed effects of habitual chocolate consumption on arterial stiffness.