Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania
Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania
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DOI：
10.1016/j.cca.2017.01.029
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发表时间：
2017-05-01
影响因子：
5
通讯作者：
Rauch, Bernhard H.
中科院分区：
文献类型：
--
作者：
Moritz, Eileen;Wegner, Danilo;Rauch, Bernhard H.
背景：1-磷酸鞘氨醇（S1 P）是一种潜在的心血管疾病（CVD）的生物标志物。迄今为止，尚未定义S1 P的参考区间。本研究旨在建立健康人血清S1 P的参考范围。我们根据波美拉尼亚健康研究（SHIP）-TREND队列的1339名健康参与者的性别和年龄确定了S1 P水平的参考区间，排除了CVD，糖尿病，高血压，代谢综合征，肝酶升高，慢性肾脏疾病III期或IV期，或体重指数（BMI）> 30 kg/m2。结果：参与者的中位年龄为41岁（第25百分位数;第75百分位数32; 51），65%为女性。S1 P的中位血清浓度为0.804（0.694; 0.920）μ mol/L。未观察到与性别和年龄的相关性。总体参考区间为0.534-1.242 μ mol/L（第2.5;第97.5百分位数）。进一步排除吸烟者、BMI > 25 kg/m2或血脂水平升高的个体并没有显著影响S1 P的中位数浓度。结论：本研究提供了健康个体血清S1 P的参考区间。总血清SW浓度与年龄、性别、BMI或吸烟状况无关。(C)2017 Elsevier B. V.版权所有。
Background: The bioactive signaling lipid sphingosine-1-phosphate (S1P) is a potential biomarker for cardiovascular disease (CVD). To date, no reference intervals for S1P have been defined. This study aims to establish a reference range for serum S1P in healthy individuals.Methods: We determined reference intervals for S1P levels according to gender and age in a sample of 1339 healthy participants of the Study of Health in Pomerania (SHIP)-TREND cohort after exclusion of subjects with CVD, diabetes mellitus, hypertension, metabolic syndrome, elevated liver enzymes, chronic kidney disease stadium III or IV, or body mass index (BMI) > 30 kg/m(2). Serum S1P was measured by liquid chromatography-tandem mass spectrometry.Results: The median age of the participants was 41 (25th; 75th percentile 32; 51) years, 65% were women. The median serum concentration of S1P was 0.804 (0.694; 0.920) mu mol/L. No association with gender and age was observed. The overall reference interval was 0.534-1.242 mu mol/L (2.5th; 97.5th percentile). Further exclusion of smokers, individuals with BMI > 25 kg/m(2) or elevated lipid levels did not significantly affect median S1P concentrations.Conclusions: This study provides reference intervals for serum S1P in healthy individuals. Total serum SW concentrations vary irrespectively of age, gender, BMI or smoking status. (C) 2017 Elsevier B.V. All rights reserved.