Radioprotection of tumor and normal tissues by thiophosphate compounds
Radioprotection of tumor and normal tissues by thiophosphate compounds
复制标题
硫代磷酸盐化合物对肿瘤和正常组织的辐射防护
作者：
T. Phillips;L. Kane;J. Utley
测定了抗辐射硫代磷酸化合物WR638(S-[2-氨基乙基]硫代硫酸钠)和WR2721(S-2-[3-氨丙氨基]乙基硫代硫酸酯)对广泛的正常组织和肿瘤终点的疗效。剂量修正因子(D.M.F.)取小鼠皮肤、小肠、骨髓、食道、肺、肾等组织。还获得了P-388白血病、体外检测EMT-6小鼠乳腺癌和EMT-6乳腺癌治愈情况的D.M.F.值。正常组织的D.M.F.值从肺的1.2到骨髓CFU的3，肿瘤的D.M.F.值从治愈EMT-6癌的1.3到P-388白血病的平均生存时间2.2。在肿瘤和正常组织系统中，随着剂量的增加，剂量修正因子似乎都在减少。肿瘤的保护程度似乎与其血管化和缺氧细胞成分有关。尽管治愈实体EMT-6癌的D.M.F.似乎比单次剂量的正常组织低，但目前可用的数据不允许人们预测临床上使用多个小剂量会产生这样的有益效果。
The efficacy of the radioprotective thiophosphate compounds WR638 (sodium hydrogen S‐[2 aminoethyl] phosphorothioate) and WR2721 (S‐2‐[3‐amino‐propylamino] ethyl phosphorothioate) was determined for a wide range of normal tissue and tumor endpoints. Dose‐modifying factors (D.M.F.) were obtained for mouse skin, small intestine, bone marrow, esophagus, lung, and kidney. D.M.F. values were also obtained for the P‐388 leukemia, the EMT‐6 mouse mammary carcinoma assayed in vitro, and the EMT‐6 mammary carcinoma assaysed for cure. The D.M.F. values obtained for normal tissue ranged from 1.2 for lung to 3 for bone marrow CFU's. The D.M.F. values for tumor ranged from 1.3 for cure of the EMT‐6 carcinoma to 2.2 for mean survival time in the P‐388 leukemia. There appears to be a decreasing dose‐modifying factor as a function of increasing dose in both tumor and normal tissue systems. The degree of protection afforded tumors appears to relate to their vascularization and their anoxic cell component. Although the D.M.F. obtained for cure of the solid EMT‐6 carcinoma would appear to be lower than for normal tissues with single doses, the data presently available do not allow one to predict that such a beneficial effect would occur with the multiple small doses used clinically.