The genetics of juvenile idiopathic arthritis: what is new in 2010?
The genetics of juvenile idiopathic arthritis: what is new in 2010?
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DOI：
10.1007/s11926-010-0087-0
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发表时间：
2010-04-01
影响因子：
5
通讯作者：
Prahalad, Sampath
中科院分区：
文献类型：
--
作者：
Angeles-Han, Sheila;Prahalad, Sampath
幼年特发性关节炎(JIA)是儿童慢性关节炎最常见的原因，据信受到遗传因素的影响。最近对JIA的遗传学研究不仅证实了所提出的遗传关联，而且还导致了对新的遗传关联的认识。对特定基因的研究是在共享自身免疫的前提下进行的，其中易患其他自身免疫表型的基因变异也可能导致对JIA的易感性。全基因组关联研究的出现加速了其他自身免疫表型中非人类白细胞抗原易感基因的检测，并可能发现新的JIA相关变异。本文重点介绍了JIA基因研究的最新进展。
Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is believed to be influenced by genetic factors. Recent studies on the genetics of JIA have not only validated proposed genetic associations but have also led to the recognition of novel genetic associations. Studies of specific genes have been modeled on the premise of shared autoimmunity, wherein genetic variants that predispose to other autoimmune phenotypes may also confer susceptibility to JIA. The advent of genome-wide association studies has accelerated the detection of non-HLA susceptibility loci in other autoimmune phenotypes and is likely to uncover novel JIA-associated variants as well. This review highlights recent genetic investigations of JIA.