Stripline-based microfluidic devices for high-resolution NMR spectroscopy
Stripline-based microfluidic devices for high-resolution NMR spectroscopy
复制标题
用于高分辨率核磁共振波谱的基于带状线的微流体装置
DOI：
10.3990/1.9789036528986
复制
发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
J. Bart
中科院分区：
文献类型：
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作者：
J. Bart
研究了一种芯片集成核磁共振分析的新途径。对于有限质量样品的核磁共振分析，几十年来的研究主要集中在微流体基板上的微螺线管或平面螺旋检测线圈上。由于这些方法受静态场畸变的影响而导致分辨率差，我们提出了一种新的设计，它与圆形线圈不同。我们设计的基本元素是rf带状线，它可以在单层光刻工艺中定义，并且可以完全扩展到特定的样品尺寸。由于不复杂的“线圈”几何形状，静态场失真非常低，从而产生高分辨率的检测系统。集成了微流控通道，使该芯片能够进行流内测量。与传统的核磁共振系统相比，该设备的灵敏度更高，并且在芯片上实现了最高的核磁共振分辨率。
A novel route towards microchip integrated NMR analysis was studied. For NMR analysis of mass-limited samples, research has focussed for decennia on microsolenoidal or planar helical detection coils on microfluidic substrates. Since these approaches suffer from static field distortion resulting in bad resolution, we have proposed a novel design which departs from circular shaped coils. The basic element in our design is an rf-stripline which can be defined in a single layer lithographic process and which is fully scalable to specific sample dimensions. Due to the non-complicated ‘coil’ geometry, the static field distortion is very low, resulting in a high resolution detection system. A microfluidic channel was integrated, which made this chip feasible for in-flow measurements. With this device we have shown an increased sensitivity compared to conventional NMR systems, and the highest NMR resolution ever achieved on chip.