Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis.
Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis.
复制标题
对 MUC1 糖蛋白的思考：亚型在致癌作用中的隐藏潜力。
DOI：
10.1111/apm.12587
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Santos-Silva,Filipe
中科院分区：
文献类型：
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作者：
Sousa,AndreiaM;Grandgenett,PaulM;David,Leonor;Almeida,Raquel;Hollingsworth,MichaelAnthony;Santos-Silva,Filipe
粘蛋白1（MUC1）由于其在正常细胞和肿瘤细胞中显示的大量功能而被描述为复兴分子。这种膜系糖蛋白在大多数上皮癌中过表达和异常糖基化，参与与恶性表型获得相关的几个过程。MUC1在多肽和聚糖对应物中具有高度多态性结构，MUC1变异性与包括癌症在内的多种疾病的易感性相关。已经对全长MUC1蛋白的生化特征和生物学功能进行了表征，剩下的是澄清过多MUC1同种型对细胞动力学的真实的影响。本文综述了MUC1在肿瘤发生过程中的作用，重点介绍了MUC1在细胞分化中的作用，并揭示了MUC1亚型参与恶性表型的新证据。
Mucin 1 (MUC1) has been described as the renaissance molecule due to the large set of functions it displays in both normal and neoplastic cells. This membrane‐tethered glycoprotein is overexpressed and aberrantly glycosylated in most epithelial cancers, being involved in several processes related with malignant phenotype acquisition. With a highly polymorphic structure, both in the polypeptide and glycan counterparts, MUC1 variability has been associated with susceptibility to several diseases, including cancer. Biochemical features and biological functions have been characterized upon the full‐length MUC1 protein, remaining to clarify the real impact on cell dynamics of the plethora of MUC1 isoforms. This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of MUC1 isoforms involvement in malignant phenotype.