Influence of ion pairing salts on the transcorneal permeability of ionized sulfonamides.
Influence of ion pairing salts on the transcorneal permeability of ionized sulfonamides.
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离子对盐对离子磺酰胺经角膜渗透性的影响。
DOI：
10.1089/jop.1992.8.233
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Buck,RH
中科院分区：
文献类型：
--
作者：
Conroy,CW;Buck,RH
本文研究了阳离子铵、膦、砷离子配对盐以及阴离子有机和无机盐对离解磺胺碳酸酐酶抑制剂经角膜通透性的影响。对苯甲酰胺、甲氯甲唑胺、MK-927和季铵磺胺进行了检测。在配对盐的存在下，第一种化合物的一级速率常数(KIN)的增加是基础速率的15倍，其余三种药物的增加较小。离子配对盐可能是一种提高高度电离药物经角膜渗透性的方法。
The effects of cationic ammonium, phosphonium, and arsonium ion pairing salts as well as anionic organic and inorganic salts on the transcorneal permeability of ionized sulfonamide carbonic anhydrase inhibitors have been studied in the excised rabbit cornea. Benzolamide, thchloromethazolamide (TCM), MK-927, and quaternary ammonium sulfonamide (QAS) were examined. The enhancement in the first-order rate constants (kin) for the first compound in the presence of pairing salts was as much as 15 times the basal rate, with smaller increases seen with the remaining three drugs. Ion pairing salts may represent a means for enhancing the transcorneal permeability of highly ionized drugs.