Adherence logger for a dry powder inhaler: A new device for medical adherence research
Adherence logger for a dry powder inhaler: A new device for medical adherence research
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DOI：
10.1016/j.jaci.2004.07.017
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发表时间：
2004-10-01
影响因子：
14.2
通讯作者：
Apter, AJ
中科院分区：
文献类型：
--
作者：
Bogen, D;Apter, AJ
背景：吸入类固醇治疗方案的依从性通常较差。寻找提高依从性的方法取决于可靠测量吸入器使用时间和日期以及检测故意剂量倾卸的能力。流行的新型干粉吸入器没有这样的监测器。目的：开发和测试干粉吸入器的电子监测器，提供使用时间和日期的信息。方法：开发和测试 Advair Diskus 干粉吸入器的电子依从性监测器。在该装置中，通过用磁传感器检测和记录吸入器中药物输送杆的运动来确定吸入器的使用。还开发了额外的电子接口和软件，以便将依从性数据上传到计算机进行显示和分析。结果：涉及依从性监测器的多天和重复使用测试的系统和可靠性测试证明了设备的整体性能和可靠性，特别是其记录剂量输送时间和日期的能力。在重复使用测试中，剂量输送杆的 300 次连续驱动被正确地感知和记录，没有错误。结论：使用简单、成本低、可重复使用的依从性监测仪可以准确记录吸入器的使用时间和日期，从而可以对使用 Advair Diskus 干粉吸入器的患者进行临床监测和依从性研究。相同的技术应该适用于其他干粉吸入器，包括 Pulmicort Tubuhaler 和 Symbicort Tubuhaler。
Background: Adherence to inhaled steroid regimens is frequently poor. Finding ways to improve adherence depends on the ability to measure time and date of inhaler use reliably and to detect deliberate dose dumping. There is no such monitor for the popular new dry powder inhalers.Objective: To develop and test an electronic monitor for a dry powder inhaler that will provide information on the time and date of use.Methods: An electronic adherence monitor for the Advair Diskus dry powder inhaler was developed and tested. In this device, inhaler use is determined by detecting and recording the motion of the drug delivery lever in the inhaler with a magnetic sensor. An additional electronic interface and software were also developed to allow the adherence data to be uploaded to a computer for display and analysis.Results: System and reliability tests involving multiple-day and repeated-use tests of the adherence monitor demonstrate the overall performance and reliability of the device, and specifically its ability to record the time and date of dose delivery. In the repeated-use test, 300 successive actuations of the dose delivery lever were correctly sensed and recorded without error.Conclusion: The simple-to-use, low-cost, reusable adherence monitor accurately records time and date of inhaler use and thus allows clinical monitoring and adherence studies in patients using the Advair Diskus dry powder inhaler. The same technology should be adaptable to other dry powder inhalers, including the Pulmicort Tubuhaler and the Symbicort Tubuhaler.