Distribution of bone mineral content is associated with body weight and exercise capacity in patients with COPD
Distribution of bone mineral content is associated with body weight and exercise capacity in patients with COPD
复制标题
COPD患者骨矿物质含量分布与体重和运动能力相关
作者：
Yamamoto Y;Yoshikawa M;Tomoda K;Fujita Y;Yamauchi M;Fukuoka A;Tamaki S;Koyama N;Kimura H
背景：虽然低骨矿物质密度是非常普遍的慢性阻塞性肺疾病（COPD）患者，减少的骨量的分布还没有得到充分阐明。Objective. Objective. To确定COPD患者的局部骨量丢失，并调查是否分布的变化可能与体重减轻和功能capability.Methods：体重指数（BMI）进行评估，并推导出身高平方指数的骨矿物质含量指数（BMCI）的手臂，腿和躯干的双能X线吸收测定法在45名男性COPD患者和12名年龄和性别匹配的对照组。结果：COPD患者全身骨、下肢和躯干的BMCI均低于对照组，但两组间臂部的BMCI相似。BMI与3个节段的BMCI均显著相关。躯干中的骨矿物质含量（BMC），表示为总BMC的百分比（BMC躯干/总BMC），与BMI显著相关。结论：躯干骨矿物质含量降低存在地区差异，但躯干骨矿物质含量的显著降低与气流受限程度无关，而与体重减轻和运动不耐受有关。这些数据表明，体重减轻和运动不耐受是COPD患者椎体骨折的重要危险因素。
Background:Although low bone mineral density is highly prevalent in patients with chronic obstructive pulmonary disease (COPD), the distribution of the reduced bone mass has not been fully elucidated.Objectives:To determine regional bone mass loss in patients with COPD and investigate whether the change in distribution may be associated with body weight loss and functional capacity.Methods:Body mass index (BMI) was assessed, and height squared indices were derived for the bone mineral content index (BMCI) of the arms, legs and trunk by dual-energy X-ray absorptiometry in 45 male patients with COPD and 12 age- and sex-matched control subjects. Pulmonary function tests were performed, and maximal oxygen uptake (V·O2max) was measured.Results:The BMCI was lower in the total bone, legs and trunk of patients with COPD than in control subjects, although the BMCI in the arms was similar between the groups. BMI correlated significantly with the BMCI in all 3 segments. Bone mineral content (BMC) in the trunk, expressed as a percentage of total BMC (BMC trunk/total BMC), correlated significantly with BMI. The BMCI in the trunk was closely related with V·O2max but not with airflow limitation.Conclusions:There was a regional difference in BMC reduction, but a predominant reduction of bone mass in the trunk was not associated with the severity of airflow limitation but rather with body weight loss and exercise intolerance. These data suggest that body weight loss and exercise intolerance are important risk factors for vertebral fracture in patients with COPD.