Determinants of eczema: population-based cross-sectional study in Germany
Determinants of eczema: population-based cross-sectional study in Germany
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DOI：
10.1111/j.1398-9995.2010.02464.x
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发表时间：
2011-02-01
期刊：
影响因子：
12.4
通讯作者：
Schmitt, J.
中科院分区：
文献类型：
--
作者：
Apfelbacher, C. J.;Diepgen, T. L.;Schmitt, J.
P>背景：湿疹是一种慢性炎症性皮肤病，是儿童和青少年最常见的慢性疾病之一。这是本研究的目的，以调查德国儿童和青少年湿疹的决定因素。方法：数据来自德国采访和检查调查儿童和青少年（KIGGS），全国性的横断面代表性调查，2003年至2006年之间进行的公共使用文件，包括17 641名0-17岁的儿童（应答率：66.6%）。我们调查了一组广泛的环境和生活方式的暴露与以往医生诊断的湿疹通过单变量分析和多变量logistic回归modeling.Results的关联：以往医生诊断的湿疹的加权患病率为13.2% [95%置信区间（CI）12.5-13.9%]。在多变量分析中，父母过敏（OR 1.94，95%CI 1.72-2.19），父母报告的出生后感染（OR 1.45，95%CI 1.05-2.00）和父母报告的出生后黄疸（OR 1.27，95%CI 1.04-1.54）显着正相关。移民（OR 0.63，95%CI 0.49-0.80）和养狗（OR 0.78，95%CI 0.64-0.96）与湿疹呈显著负相关。其他生活方式（怀孕期间饮酒）和环境因素（墙壁上的霉菌、宠物、来自东/西德国）与湿疹没有显着相关。结论：这项研究表明过敏家族史是湿疹的最强决定因素。围产期健康问题与湿疹有关，指出早期生活因素在湿疹表现中的重要性。
P>Background:Eczema is a chronic inflammatory skin disease and is among the most frequent chronic conditions in childhood and adolescence. It is the aim of this study to investigate determinants of eczema in German children and adolescents.Methods:Data were drawn from the public use files of the German Interview and Examination Survey for Children and Adolescents (KIGGS), a nationwide cross-sectional representative survey conducted between 2003 and 2006, including 17 641 children aged 0-17 (response rate: 66.6%). We investigated the association of a broad set of environmental and lifestyle exposures with ever physician-diagnosed eczema by means of univariable analyses and multivariable logistic regression modelling.Results:The weighted prevalence of ever physician-diagnosed eczema was 13.2% [95% confidence interval (CI) 12.5-13.9%]. In multivariable analysis, significant positive associations of parental allergies (OR 1.94, 95% CI 1.72-2.19), parent-reported infection after birth (OR 1.45, 95% CI 1.05-2.00) and parent-reported jaundice after birth (OR 1.27, 95% CI 1.04-1.54) were revealed. Being a migrant (OR 0.63, 95% CI 0.49-0.80) and keeping a dog (OR 0.78, 95% CI 0.64-0.96) showed significant inverse associations with eczema. Other lifestyle (alcohol consumption during pregnancy) and environmental factors (mould on the walls, pets, origin from East/West Germany) were not significantly related to eczema.Conclusions:This study suggests that a family history of allergies is the strongest determinant of eczema. Perinatal health problems were associated with eczema, pointing to the importance of early life factors in the manifestation of eczema.