Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia
Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia
复制标题
DOI：
10.1002/hbm.20179
复制
发表时间：
2006-03-01
影响因子：
4.8
通讯作者：
Howard, RJ
中科院分区：
文献类型：
--
作者：
Jones, DK;Catani, M;Howard, RJ
扩散张量磁共振成像（DT-MRI）以前曾被用来研究精神分裂症的白质束，但结果不一致。该研究的目的是使用一种新方法对早发性精神分裂症的额颞束进行束特异性测量。我们假设，通过进行特定束的测量，可以在精神分裂症的特定束中揭示明显的弥散异常。通过使用扩散张量纤维束成像对扣带回、钩突、上纵向和下额枕束进行 3D 重建，将扩散各向异性和平均扩散率的测量定位在额颞束内。我们检验假设的能力受到了限制，因为我们发现了一个重要且令人惊讶的发现，即年龄对精神分裂症患者基于 DT-MRI 的测量的影响方式与对照组不同，尤其是左上纵束。我们研究的最年轻的精神分裂症患者的弥散各向异性低于年龄匹配的对照受试者，但这种差异随着年龄的增加而减小。这项研究的主要结论是，由于各组之间大脑成熟度存在与年龄相关的潜在差异，因此直接比较精神分裂症患者和对照受试者之间基于 DT-MRI 的绝对测量值可能会存在问题并具有误导性。
Diffusion tenser magnetic resonance imaging (DT-MRI) has previously been used to investigate white matter tracts in schizophrenia, with inconsistent results. The aim of the study was to use a novel method for tract-specific measurements of fronto-temporal fasciculi in early-onset schizophrenia. We hypothesized that by making tract-specific measurements, clear diffusion abnormalities would be revealed in specific fasciculi in schizophrenia. Measurements of diffusion anisotropy and mean diffusivity were localized within fronto-temporal fasciculi by forming 3-D reconstructions of the cingulum, uncinate, superior longitudinal, and inferior fronto-occipital fasciculi using diffusion tenser tractography. We were limited in our ability to test our hypothesis by the important and surprising finding that age affected DT-MRI-based measures in schizophrenia patients in a different way from comparison subjects, most notably in the left superior longitudinal fasciculus. The youngest schizophrenia patients that we studied had lower diffusion anisotropy than age-matched comparison subjects, but this difference diminished with increasing age. The main conclusion of this study was that direct comparisons of absolute DT-MRI-based measures between individuals with schizophrenia and comparison subjects may be problematic and misleading because of underlying age-related differences in brain maturation between groups.