Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests
Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests
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DOI：
10.1136/thorax.55.3.198
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发表时间：
2000-03-01
期刊：
影响因子：
10
通讯作者：
Hansell, DM
中科院分区：
文献类型：
--
作者：
Roberts, HR;Wells, AU;Hansell, DM
背景--阻塞性缺陷在支气管扩张症中很常见，但气流阻塞的病理生理学基础仍不确定。高分辨率CT扫描现在可以量化静态形态异常，以及呼气CT扫描上显示的动态变化。方法：对100例同时行肺功能检查的支扩患者的CT扫描吸气相和呼气相特征进行半定量评分。结果单因素分析中，支气管壁增厚的程度和程度、呼气相密度降低的程度与气流阻塞的严重程度密切相关；1秒用力呼气容积下降(FEV1)与呼气CT衰减程度关系最密切(R-S=-0.55，P
Background-An obstructive defect is usual in bronchiectasis, but the pathophysiological basis of airflow obstruction remains uncertain. High resolution computed tomographic (CT) scanning now allows quantitation of static morphological abnormalities, as well as dynamic changes shown on expiratory CT scans. The aim of this study was to determine which static and dynamic structural abnormalities on the CT scan are associated with airflow obstruction in bronchiectasis.Methods-The inspiratory and expiratory features on the CT scan of 100 patients with bronchiectasis undergoing concurrent lung function tests were scored semiquantitatively by three observers.Results-On univariate analysis the extent and severity of bronchiectasis, the severity of bronchial wall thickening, and the extent of decreased attenuation on the expiratory CT scan correlated strongly with the severity of airflow obstruction; the closest relationship was seen between decreased forced expiratory volume in one second (FEV,) and the extent of decreased attenuation on the expiratory CT scan (R-s = -0.55, p