Cancer vaccination at older age.
Cancer vaccination at older age.
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老年时接种癌症疫苗。
DOI：
10.1159/000343596
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Gravekamp,Claudia
中科院分区：
文献类型：
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作者：
Gravekamp,Claudia
由于T细胞无反应性，癌症疫苗在老年人中的效果不如年轻人。这是由免疫系统的各种年龄相关变化引起的，例如缺乏幼稚T细胞，T细胞和抗原呈递细胞活化途径的缺陷以及肿瘤微环境的年龄相关变化。先天免疫系统的自然杀伤细胞、自然杀伤T细胞和γδT细胞也随年龄变化，但这些反应可能比老年人的适应性免疫反应更容易改善。本章比较了各种研究，涉及老年人和癌症患者的适应性和先天免疫反应，以及年轻和老年人的癌症疫苗接种。最后，在老年癌症疫苗接种的潜在新方向进行了讨论。
Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness. This is caused by various age-related changes of the immune system, such as lack of naïve T cells, defects in activation pathways of T cells and antigen-presenting cells, and age-related changes in the tumor microenvironment. Natural killer, natural killer T cells, and γδT cells of the innate immune system also change with age but these responses may be more susceptible for improvement than adaptive immune responses at older age. This chapter compares various studies involving adaptive and innate immune responses in elderly and cancer patients, as well as cancer vaccination at young and old age. Finally, potential new directions in cancer vaccination at older age are discussed.