Pregnancy weight gain by gestational age and stillbirth: a population-based cohort study.
Pregnancy weight gain by gestational age and stillbirth: a population-based cohort study.
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DOI：
10.1111/1471-0528.15034
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Stephansson O
中科院分区：
文献类型：
--
作者：
Johansson K;Hutcheon JA;Bodnar LM;Cnattingius S;Stephansson O
研究总妊娠和妊娠早期（<22周）体重增加与死胎风险之间的关系，按妊娠早期体重指数（BMI）分层。基于人群的队列研究瑞典斯德哥尔摩-哥特兰大区。单胎妊娠女性（n = 160 560）。将妊娠体重增加标准化为孕龄特异性z评分。对于总妊娠体重增加的分析，使用了具有发病率密度抽样方法的匹配设计。研究结果还与目前医学研究所（IOM）的体重增加建议进行了对比。死产定义为妊娠≥22周时胎儿死亡。对于所有BMI类别，在体重增加z评分为-2.0 SD至+2.0 SD的范围内，总体重增加或妊娠早期体重增加与死产之间无统计学相关性。在正常体重的女性中，与参考类别相比，总体重增加较低（-2.0至-1.0 SD）和较高（+1.0至+1.9 SD）的死产校正比值比分别为0.85（95% CI; 0.48-1.49）和1.03（0.60-1.77）。此外，在IOM目前推荐的体重增加范围内，总体重增加或妊娠早期体重增加与死产之间没有关联。对于大多数BMI类别，在体重增加值的极端值（<-2.0 SD和≥2.0 SD）的点估计值表明低体重增加的保护作用和高体重增加的风险增加，但估计值不精确，没有统计学意义。我们发现，在大多数女性经历的体重增加范围内，总体重或妊娠早期体重增加与死产之间没有关联。在大多数妇女中，怀孕期间体重增加与死产之间没有联系。在大多数妇女中，怀孕期间体重增加与死产之间没有联系。
To study the association between total and early pregnancy (<22 completed weeks) weight gain and risk of stillbirth, stratified by early‐pregnancy body mass index (BMI). Population‐based cohort study. Stockholm‐Gotland Region, Sweden. Pregnant women with singleton births (n = 160 560). Pregnancy weight gain was standardised into gestational age‐specific z‐scores. For analyses of total pregnancy weight gain, a matched design with an incidence density sampling approach was used. Findings were also contrasted with current Institute of Medicine (IOM) weight gain recommendations. Stillbirth defined as fetal death at ≥22 completed weeks of gestation. For all BMI categories, there was no statistical association between total or early pregnancy weight gain and stillbirth within the range of a weight gain z‐score of −2.0 SD to +2.0 SD. Among normal‐weight women, the adjusted odds ratio of stillbirth for lower (−2.0 to −1.0 SD) and higher (+1.0 to +1.9 SD) total weight gain was 0.85 (95% CI; 0.48–1.49) and 1.03 (0.60–1.77), respectively, as compared with the reference category. Further, there were no associations between total or early pregnancy weight gain and stillbirth within the range of weight gain currently recommended by the IOM. For the majority of the BMI categories, the point estimates at the extremes of weight gain values (<−2.0SD and ≥2.0 SD) suggested protective effects of low weight gain and increased risks of high weight gain, but estimates were imprecise and not statistically significant. We found no associations between total or early pregnancy weight gain and stillbirth across the range of weight gain experienced by most women. There was no association between weight gain during pregnancy and stillbirth among most women. Tweetable abstract There was no association between weight gain during pregnancy and stillbirth among most women.
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影响因子：
3.4
作者：
Cnattingius, S;Stephansson, O
通讯作者：
Stephansson, O
DOI：
10.1177/140349489001800209
发表时间：
1990-01-01
期刊：
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE
影响因子：
--
作者：
CNATTINGIUS, S;ERICSON, A;KALLEN, B
通讯作者：
KALLEN, B
影响因子：
168.9
作者：
Flenady, Vicki;Wojcieszek, Aleena M.;Goldenberg, Robert L.
通讯作者：
Goldenberg, Robert L.
影响因子：
168.9
作者：
Froen, J. Frederik;Friberg, Ingrid K.;Temmerman, Marleen
通讯作者：
Temmerman, Marleen
影响因子：
7.1
作者：
Johansson, Kari;Hutcheon, Jennifer A.;Cnattingius, Sven
通讯作者：
Cnattingius, Sven