Histopathological predictor for regional lymph node metastasis in gastric cancer
Histopathological predictor for regional lymph node metastasis in gastric cancer
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DOI：
10.1007/s00428-008-0717-3
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发表时间：
2009-02-01
期刊：
影响因子：
3.5
通讯作者：
Ishii, Toshiharu
中科院分区：
文献类型：
--
作者：
Morita, Hiroshi;Ishikawa, Yukio;Ishii, Toshiharu
胃癌区域淋巴转移是判断患者预后的明确指标。这项研究的目的是在所有可能的组织病理学参数中确定淋巴结转移的预测因素，特别是通过对淋巴管和血管进行客观区分。对210例有或无淋巴结转移的原发胃癌患者，根据常规病理组织学参数，采用抗血清识别的淋巴管内皮细胞透明质酸受体-1(LYVE-1)、血管性血友病因子(Von Willebrand)和淋巴管生成促进剂血管内皮生长因子-C(VEGF-C)抗体进行免疫组织化学检测。结果的多元回归分析表明，在癌症侵袭的任何阶段，只有淋巴侵袭是显著的独立预测淋巴转移的因素。VEGF-C的表达与早期胃癌的淋巴结转移有一定关系。因此，用LYVE-1抗体识别淋巴侵袭有助于预测胃癌的区域淋巴转移。
Regional lymph node metastasis in gastric cancer is a definitive indicator of the patient's prognosis. The goal of this study was to identify the predictors for lymph node metastasis among all the possible histopathological parameters, especially by conducting an objective discrimination of the lymphatic and blood vessels. A total of 210 resected primary gastric cancers with or without lymph node metastasis were evaluated based on the conventional histopathological parameters together with immunohistochemistry using antisera-recognizing lymphatic endothelial hyaluronan receptor-1 (LYVE-1), von Willebrand factor, and lymphangiogenesis promoter vascular endothelial growth factor-C (VEGF-C) antibodies. A multivariate regression analyses of the results indicated that only lymphatic invasion was a significant independent predictor of lymph node metastasis at any stage of cancer invasion. VEGF-C expression was partially related to lymph node metastasis in early gastric cancer. The identification of lymphatic invasion by LYVE-1 antibody is therefore useful to predict regional lymph node metastasis in gastric cancer.