Cortical map reorganization enabled by nucleus basalis activity
Cortical map reorganization enabled by nucleus basalis activity
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DOI：
10.1126/science.279.5357.1714
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发表时间：
1998-03-13
期刊：
影响因子：
56.9
通讯作者：
Merzenich, MM
中科院分区：
文献类型：
--
作者：
Kilgard, MP;Merzenich, MM
关于大脑皮质选择性地改善行为重要刺激的神经表征，而忽略无关刺激的机制，人们知之甚少。弥散神经调节系统可能通过充当教师来标记重要的刺激，从而促进皮质的可塑性。这项研究表明，间歇性电刺激基底核，配合听觉刺激，导致成年大鼠初级听觉皮质的大规模渐进性重组。感受野的大小可以缩小、扩大或保持不变，这取决于与基底核激活配对的声刺激的特定参数。这种不同的可塑性与不同类型的行为训练导致的感受野重塑是平行的。这一结果表明，输入特征可能能够驱动接受场的适当改变，而不依赖于任务的外显知识。这些发现还表明，基底前脑在表象可塑性中起着积极的指导作用。
Little is known about the mechanisms that allow the cortex to selectively improve the neural representations of behaviorally important stimuli while ignoring irrelevant stimuli. Diffuse neuromodulatory systems may facilitate cortical plasticity by acting as teachers to mark important stimuli. This study demonstrates that episodic electrical stimulation of the nucleus basalis, paired with an auditory stimulus, results in a massive progressive reorganization of the primary auditory cortex in the adult rat. Receptive field sizes can be narrowed, broadened, or left unaltered depending on specific parameters of the acoustic stimulus paired with nucleus basalis activation. This differential plasticity parallels the receptive field remodeling that results from different types of behavioral training. This result suggests that input characteristics may be able to drive appropriate alterations of receptive fields independently of explicit knowledge of the task. These findings also suggest that the basal forebrain plays an active instructional role in representational plasticity.