Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases.
Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases.
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DOI：
10.3389/fimmu.2021.798211
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发表时间：
2021
影响因子：
7.3
通讯作者：
Kusumbe AP
中科院分区：
文献类型：
--
作者：
Kumar N;Saraber P;Ding Z;Kusumbe AP
骨骼系统中的骨骼和关节由不同的细胞类型组成，包括血管龛、骨细胞、结缔组织细胞和矿物质沉积，并调节全身内稳态。骨骼系统是维持力量和血脉生成的能力。骨内有血液和免疫细胞及其祖细胞，血管细胞提供了几种免疫细胞类型的小生境。骨中的血管在表型和功能上是多样的，随着年龄的增长，不同的毛细血管亚型表现出显著的变化。骨脉管系统对骨生成和造血具有特殊影响，并且脉管系统的失调与多种血液和骨骼疾病相关。衰老与造血功能紊乱、骨生成丧失、脂肪生成增加以及免疫反应和免疫细胞产生减少有关。内皮细胞和血管周围细胞影响免疫细胞的产生，并在炎症过程中发挥关键作用。在这里，我们讨论了正常和适应不良的血管壁龛在骨发育，稳态，衰老和骨疾病，如类风湿性关节炎和骨关节炎。此外，我们还讨论了血管龛在骨恶性肿瘤中的作用。
The bones and joints in the skeletal system are composed of diverse cell types, including vascular niches, bone cells, connective tissue cells and mineral deposits and regulate whole-body homeostasis. The capacity of maintaining strength and generation of blood lineages lies within the skeletal system. Bone harbours blood and immune cells and their progenitors, and vascular cells provide several immune cell type niches. Blood vessels in bone are phenotypically and functionally diverse, with distinct capillary subtypes exhibiting striking changes with age. The bone vasculature has a special impact on osteogenesis and haematopoiesis, and dysregulation of the vasculature is associated with diverse blood and bone diseases. Ageing is associated with perturbed haematopoiesis, loss of osteogenesis, increased adipogenesis and diminished immune response and immune cell production. Endothelial and perivascular cells impact immune cell production and play a crucial role during inflammation. Here, we discuss normal and maladapted vascular niches in bone during development, homeostasis, ageing and bone diseases such as rheumatoid arthritis and osteoarthritis. Further, we discuss the role of vascular niches during bone malignancy.