Development of a Short Version of the Thyroid-Related Patient-Reported Outcome ThyPRO
Development of a Short Version of the Thyroid-Related Patient-Reported Outcome ThyPRO
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DOI：
10.1089/thy.2015.0209
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发表时间：
2015-10-01
期刊：
影响因子：
6.6
通讯作者：
Feldt-Rasmussen, Ulla
中科院分区：
文献类型：
--
作者：
Watt, Torquil;Bjorner, Jakob Bue;Feldt-Rasmussen, Ulla
背景：甲状腺疾病影响生活质量（QoL）。甲状腺相关患者报告结局（ThyPRO）是一项国际综合性、经过充分验证的患者报告结局，测量甲状腺相关QoL。目前的版本是相当长的85个项目。本研究的目的是开发一种简化版本的ThyPRO，具有保存良好的测量特性。方法：对甲状腺患者的横断面（N=907）和纵向样本（N=435）进行分析。一个分级项目反应理论（IRT）模型拟合的横截面数据。通过根据IRT模型选择最适合的项目，避免跨文化非不变项目，以三个项目的简短形式量表为目标。在双因素模型中分析了7个衡量心理和社会幸福感和功能的量表以及一个总体生活质量影响项目，以制定补充综合评分。采用基于IRT的总分链接将短量表与原始量表相关联。通过一致性图、组内相关性和平均得分水平估计短型和长型之间的一致性。反应性比较的相对有效性指数，临床有效性的能力，以检测临床相关的差异，和重测信度的组内相关性。结果：简式量表中有一个四项目量表没有缩写，一个两项目量表被省略。对于11个正在进行缩写的量表，10个三个项目和一个四个项目。一个双因素模型与良好的整体拟合拟合的综合评分，包括单一的生活质量项目。短量表的反应性和临床有效性得以保留，重测信度（0.75-0.89）。短期与长期的组内相关性很高（0.89-0.98），平均量表水平相似。结论：ThyPRO的39项版本，具有良好的测量性能，并建议临床使用。
Background: Thyroid diseases affect quality of life (QoL). The Thyroid-Related Patient-Reported Outcome (ThyPRO) is an international comprehensive well-validated patient-reported outcome, measuring thyroid-related QoL. The current version is rather long85 items. The purpose of the present study was to develop an abbreviated version of the ThyPRO, with conserved good measurement properties. Methods: A cross-sectional (N=907) and a longitudinal sample (N=435) of thyroid patients were analyzed. A graded item response theory (IRT) model was fitted to the cross-sectional data. Short-form scales with three items were aimed for, by selecting items with best fit according to the IRT model, avoiding cross-culturally noninvariant items. Seven scales measuring mental and social well-being and function as well as one overall QoL impact item were analyzed in a bifactor model, to develop a supplementary composite score. Short-form scales were linked to original scales with IRT-based summed-score-linking. Agreement between the short and long form was estimated by agreement plots, intraclass correlations, and mean score levels. Responsiveness was compared by relative validity indices, clinical validity by ability to detect clinically relevant differences, and test-retest reliability by intra-class correlation. Results: One four-item scale was not abbreviated and one two-item scale was omitted from the short-form. For the 11 scales undergoing abbreviation, 10 with three and one with four items were developed. A bifactor model with good overall fit was fitted to the composite score, including the single QoL item. Responsiveness and clinical validity of the short-form scales were preserved, as were test-retest reliability (0.75-0.89). Short- versus long-form intraclass correlations were high (0.89-0.98), and the mean scale levels were similar. Conclusions: A 39-item version of the ThyPRO, with good measurement properties, was developed and is recommended for clinical use.