Low levels of carotenoids and retinol in involutional osteoporosis
Low levels of carotenoids and retinol in involutional osteoporosis
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DOI：
10.1016/j.bone.2005.08.003
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发表时间：
2006-02-01
期刊：
影响因子：
4.1
通讯作者：
Cherubini, A
中科院分区：
文献类型：
--
作者：
Maggio, D;Polidori, MC;Cherubini, A
先前在视黄醇补充对象中进行的流行病学研究表明，高血清水平或饮食摄入视黄醇与髋部骨折风险之间存在关联。另一方面，观察性研究显示，随着年龄的增长，饮食中摄入较多视黄醇的未补充受试者比摄入较少视黄醇的受试者骨质流失较少。这一目前尚未解释的差异表明，营养在调节视黄醇对骨骼的影响方面起着重要作用。由于视黄醇来源于动物性食物中的类维生素a和蔬菜和水果中的类胡萝卜素，我们评估了类胡萝卜素在偶发性骨质疏松症中的可能作用。因此，在有或没有严重骨质疏松症的自由生活的老年妇女中，除了视黄醇之外，还测量了β -胡萝卜素和其他类胡萝卜素的血浆水平。血浆中视黄醇和所有类胡萝卜素（叶黄素除外）的水平在骨质疏松症女性中一直低于对照组。在骨质疏松症妇女中，仅发现视黄醇与股骨颈骨密度之间存在弱关联。我们的研究表明，视黄醇具有保骨作用，这可能与某些类胡萝卜素的维生素a原活性有关。(c) 2005爱思唯尔公司版权所有。
Previous epidemiological studies conducted in retinol-supplemented subjects showed an association between high serum levels or dietary intake of retinol and risk of hip fracture. On the other side, observational studies revealed that non-supplemented subjects with higher dietary intake of retinol lose less bone with age than subjects with lower intake. This discrepancy, currently unexplained, suggests that nutrition plays a major role in conditioning the effects of retinol on bone. Since retinol is derived from both retinoids - contained in animal food - and carotenoids - contained in vegetables and fruits - we evaluated a possible role of carotenoids in involutional osteoporosis. Therefore, plasma levels of beta-carotene and other carotenoids, in addition to those of retinol, were measured in free-living, non-supplemented, elderly women with or without severe osteoporosis. Plasma levels of retinol and of all carotenoids tested, with the exception of lutein, were consistently lower in osteoporotic than in control women. A weak association was found only between retinol and femoral neck bone mineral density in osteoporotic women. Our study suggests a bone sparing effect of retinol, to which the provitamin A activity of some carotenoids might have contributed. (c) 2005 Elsevier Inc. All rights reserved.