Enantiomeric separations of primary amino compounds by nonaqueous capillary zone electrophoresis with a chiral crown ether
Enantiomeric separations of primary amino compounds by nonaqueous capillary zone electrophoresis with a chiral crown ether
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使用手性冠醚进行非水毛细管区带电泳分离伯氨基化合物的对映体
DOI：
10.1016/s0021-9673(96)00674-7
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Umeda
中科院分区：
文献类型：
--
作者：
Y. Mori;K. Ueno;T. Umeda
研究了毛细管电泳法在非水介质中拆分对映体。在含有手性冠醚(+)-18-冠-6-四羧酸的甲酰胺中，用毛细管电泳法实现了芳香胺、氨基酸和氨基醇等8种伯氨基化合物的对映体分离。在电泳液中加入四正丁基高氯酸铵作为支持电解质，提高了分离效率，实现了dl-1-苯乙胺的基线对映体分离。
The enantiomeric separation by capillary electrophoresis (CE) in non-aqueous media was examined. The enantiomeric separations of eight primary amino compounds including aromatic amines, amino acids and amino alcohols were achieved by CE in formamide containing a chiral crown ether, (+)-18-crown-6 tetracarboxylic acid. The addition of tetra-n-butylammonium perchlorate as a supporting electrolyte to the electrophoretic solution improved the separation efficiency and gave the baseline enantiomeric separation of dl-1-phenylethylamine which has not been separated by any other separation mode of CE yet.