The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals
The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals
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DOI：
10.1016/j.metabol.2006.05.003
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发表时间：
2006-09-01
影响因子：
9.8
通讯作者：
Bessesen, Daniel H.
中科院分区：
文献类型：
--
作者：
Cornier, Marc-Andre;Bergman, Bryan C.;Bessesen, Daniel H.
Insulin resistance is clearly associated with obesity. However, the role of excess energy intake per se as opposed to increased fat mass in the development of insulin resistance has not been clearly defined. It may be that the nutrient load provided by short-term overfeeding is sufficient to induce measurable changes in insulin action in skeletal muscle and the liver. We examined the effects of 3 days of overfeeding on insulin action and glucose kinetics in 13 lean (body mass index, 20.9 +/- 2.4 kg/m(2); 6 men, 7 women) and 9 reduced-obese (RO) (body mass index, 29.1 +/- 2.2 kg/m(2); 4 men, 5 women) individuals. A two-step euglycemic hyperinsulinemic clamp study (5 and 40 MU m(-2) min(-1)) with a primed, constant infusion of [6,6-H-2(2)] glucose was performed after 3 days of a weight-maintenance diet and again after 3 days of overfeeding by 50% (50% carbohydrate, 30% fat, 20% protein). At baseline, lean individuals were more insulin sensitive, as measured by glucose infusion rate, than RO individuals (12.08 +/- 0.8 vs 7.62 +/- 1.0 mg center dot kg(-1) center dot min(-1), P
