SURFACE-PROPERTIES DETERMINE BIOADHESIVE OUTCOMES - METHODS AND RESULTS
SURFACE-PROPERTIES DETERMINE BIOADHESIVE OUTCOMES - METHODS AND RESULTS
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DOI：
10.1002/jbm.820180404
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
CARTER, JM
中科院分区：
文献类型：
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作者：
BAIER, RE;MEYER, AE;CARTER, JM
本研究为不同表面能态对生物医学材料组织掺入的影响提供了实验证据。将两种具有三种不同表面能态的光滑金属植入新西兰大白兔背部的皮下筋膜平面，给予10天和20天的愈合时间。在手术放置之前和从宿主动物产生的组织胶囊中取出之后，植入物表面通过物理化学标准进行了彻底的表征。使用标准形态计量学标准对邻近组织进行定量组织病理学分析，发现与最初严格清洁的高表面能材料相比，纤维母细胞-纤维细胞细胞增加了三倍。细胞变平且活跃，通过一层薄薄的预先吸附的蛋白质主导的“调节”膜产生了顽强的结合，这种结合只有在组织本身的内聚失败时才会被破坏。相比之下，典型的低表面能材料的标准牙种植体是由一个细胞贫乏的，无粘性的胶囊“隔离”，其纤维界面与一个更厚的“调节”膜由富含脂质的粘液区分开。适当的表面处理有利于所需的生物粘附程度的优点是显而易见的。
This investigation developed experimental evidence for the influence of different surface energy states on tissue incorporation of biomedical materials. Implants of two smooth metals, each with three different surface energy states, were placed in the subdermal fascial plane of the backs of New Zealand White rabbits and were allowed healing times of 10 and 20 days. The implant surfaces were thoroughly characterized by physical‐chemical criteria prior to surgical placement and again following removal from the tissue capsules generated by the host animals. Quantitative histopathologic analysis, using standard morphometric criteria, of the adjacent tissues revealed up to a threefold increase of fibroblastic‐fibrocytic cells against the initially scrupulously cleaned, high‐surface‐energy materials. The cells were flattened and active, producing tenacious bonds through a thin pre‐adsorbed protein‐dominated “conditioning” film, that could be broken only by cohesive failure in the tissue itself. In contrast, the lower‐surface‐energy materials typical of standard dental implants were “walled off” by a cell‐poor, nonadhesive capsule with a fibrous interface separated from a thicker “conditioning” film by a lipid‐rich mucus zone. The advantages of proper surface treatment to favor the desired degree of biological adhesion are apparent.