Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 beta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia
Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 beta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia
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发表时间：
1981-11
期刊：
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通讯作者：
R. Cochran;L. Ewing;G. Niswender
中科院分区：
文献类型：
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作者：
R. Cochran;L. Ewing;G. Niswender
血清睾酮（T）5 α-雄甾烷-3 α，17 β-二醇浓度（3 α-二醇），5 α-雄甾烷-3 β，17 β-二醇（3 β-二醇）、促黄体生成激素（LH）、促卵泡激素（FSH），和催乳素（小于40个月）自发性良性前列腺增生（BPH）的比格犬，（P大于0.25）与年龄匹配的对照组或患有BPH的老年（大于60个月）比格犬的血清激素水平不同。然而，年龄匹配对照组或BPH患者的血清激素水平（2.46 +/- 0.51 pg/ml）显著高于与年龄匹配的对照组比较，P <0.05（3.93 +/- 0.35 pg/ml）和患有BPH的老年比格犬与血清雄激素浓度增加或血清促性腺激素水平变化无关，但可能与雌激素生物合成或代谢的某些变化有关。在实验的第二部分，去势和完整的比格犬进行了为期4个月的治疗，每周三次注射T，DHT，3 α-二醇，雌二醇，T +雌二醇，DHT +雌二醇，或3 α-二醇+雌二醇。正如预期的那样，T、DHT、3 α-二醇、雌二醇、LH和FSH的血清浓度根据所使用的类固醇方案而显著变化。这些结果的分析表明，前列腺重量增加的类固醇治疗，提高血清DHT浓度。然而，腺体增生，与BPH犬中所见无区别，仅当雌二醇添加到导致血清DHT浓度升高的类固醇治疗中时发生。
The serum concentration of testosterone (T) 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol), 5 alpha-androstane-3 beta , 17 beta-diol (3 beta-diol), luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin in young (less than 40 months) beagles with spontaneous benign prostatic hyperplasia (BPH) were not significantly (P greater than 0.25) different from serum hormone levels of age matched controls, or old (greater than 60 months) beagles with BPH. However, the serum hormone levels of age matched controls, or with BPH (2.46 +/- 0.51 pg per ml) was significantly (P less than 0.05) lower than that of age matched controls (3.93 +/- 0.35 pg per ml) and of old beagles with BPH is not associated with increased serum concentrations of androgens, or changes in serum levels of gonadotropins, but may be related to some change in estrogen biosynthesis or metabolism. In the second part of the experiment, castrate and intact beagles were treated for 4 months with three weekly injections of T, DHT, 3 alpha-diol, estradiol, T + estradiol, DHT + estradiol, or 3 alpha-diol + estradiol. As expected, the serum concentration of T, DHT, 3 alpha-diol, estradiol, LH, and FSH varied dramatically depending on the steroid regimen used. Analysis of these results showed that prostate weight was increased by steroid treatments which elevated the serum DHT concentration. However, glandular hyperplasia, indistinguishable from that seen in dogs with BPH, occurred only when estradiol was added to those steroid treatments which caused elevated serum DHT concentration.