Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits
Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits
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DOI：
10.1038/s41598-020-66284-3
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发表时间：
2020-06-09
影响因子：
4.6
通讯作者：
van Vliet-Ostaptchouk, Jana V.
中科院分区：
文献类型：
--
作者：
van der Meer, Thomas P.;van Faassen, Martijn;van Vliet-Ostaptchouk, Jana V.
内分泌干扰物（EDCs）与多种心脏代谢疾病有关。然而，很少有研究将生活方式考虑在内，调查内分泌干扰物的暴露和心脏代谢健康。我们的目的是评估暴露于五个对羟基苯甲酸酯，三个双酚和十三个代谢产物，共八个邻苯二甲酸酯在一般荷兰人口，并调查其与心脏代谢性状。在来自基于人群的生命线队列的662名成人受试者中，使用LC-MS/MS测量了2012年收集的24小时尿液中的21种EDC分析物。使用多变量线性模型对年龄、性别、教育、吸烟、糖尿病、体力活动和热量摄入进行调整，进行心脏代谢特征和EDC浓度之间的关联分析。进行四分位数分析以评估线性。在84-100%的样品中检测到双酚A、4种对羟基苯甲酸酯和8种邻苯二甲酸酯代谢物。校正后的MiBP和MBzP与肥胖相关性状的相关性在多重检验中是稳健的（贝塔系数，BMI：1.12，2.52;腰围：0.64，1.56; FDR：1.12，2.52，1.56，1.52，1.
Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR