Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
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DOI：
10.1126/science.1079641
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发表时间：
2003-03-21
期刊：
影响因子：
56.9
通讯作者：
Kiehn, O
中科院分区：
文献类型：
--
作者：
Kullander, K;Butt, SJB;Kiehn, O
脊髓中产生运动的局部回路被称为中央模式发生器（CPG）。这些提供了协调的双边控制的正常肢体交替的基础行走。组织哺乳动物CPG的分子是未知的。来自缺乏EphA4受体或其配体ephrinB3的小鼠的分离脊髓失去了左右肢体交替，而是表现出同步性。我们确定EphA4阳性神经元作为运动CPG的兴奋成分。我们的研究表明，戏剧性的运动变化可以发生作为局部遗传重新布线的结果，并确定了正常运动行为发展所需的基因。
Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the locomotor CPG. Our study shows that dramatic locomotor changes can occur as a consequence of local genetic rewiring and identifies genes required for the development of normal locomotor behavior.