Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease.
Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease.
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DOI：
10.1513/pats.200504-029sr
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Owen, Caroline A
中科院分区：
文献类型：
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作者：
Owen, Caroline A
现在有令人信服的证据表明，蛋白酶和氧化应激在慢性阻塞性肺疾病的以下病理中起致病作用：气道扩大;气道、肺小叶和肺泡腔中的慢性炎症;以及大气道中的粘液分泌过多。蛋白酶和氧化剂也可能有助于小气道的重塑过程。此外，数据显示蛋白酶类之间以及蛋白酶和氧化剂之间的相互作用，这会放大慢性阻塞性肺疾病中的肺部炎症和损伤。本文综述了蛋白酶和氧化剂的生物学作用，它们在慢性阻塞性肺疾病发病机制中的作用，以及它们作为治疗靶点的潜力。
There is now compelling evidence that proteinases and oxidative stress play pathogenetic roles in the following pathologies in chronic obstructive pulmonary disease: airspace enlargement; chronic inflammation in the airways, lung interstitium, and alveolar space; and mucus hypersecretion in the large airways. Proteinases and oxidants may also contribute to remodeling processes in the small airways. In addition, data are emerging that show interactions between classes of proteinases and between proteinases and oxidants, which amplify lung inflammation and injury in chronic obstructive pulmonary disease. This review discusses the biologic roles of proteinases and oxidants, their roles in the pathogenesis of chronic obstructive pulmonary disease, and their potential as targets for therapy.