Interrelationship between Polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in the Netherlands
Interrelationship between Polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in the Netherlands
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DOI：
10.1128/jcm.43.5.2441-2443.2005
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发表时间：
2005-05-01
影响因子：
9.4
通讯作者：
van der Ende, A
中科院分区：
文献类型：
--
作者：
Pannekoek, Y;Spaargaren, J;van der Ende, A
对荷兰沙眼衣原体分离株的印加变异进行了研究。在98株菌株中，有两株携带带有提前终止密码子的印加基因，缺乏印加基因，不具有融合性，而96株含有完整的印加基因，表达印加基因，并具有筋膜基因。在这96个菌株中，发现了9个印加序列类型，其中最常见的3个(88%的菌株)随机分布在有症状和无症状的患者中。
IncA variation among Dutch Chlamydia trachomatis isolates was investigated. Of 98 strains, two carried an incA with a premature stop codon, lacked IncA, and were nonfusogenic, while 96 contained an intact incA, expressed IncA, and were fasogenic. Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients.