Development of Somatosensory Perception in Children: A Longitudinal QST-Study
Development of Somatosensory Perception in Children: A Longitudinal QST-Study
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DOI：
10.1055/s-0032-1307450
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发表时间：
2012-02-01
期刊：
影响因子：
1.4
通讯作者：
Blankenburg, Markus
中科院分区：
文献类型：
--
作者：
Hirschfeld, Gerrit;Zernikow, Boris;Blankenburg, Markus
对儿童体感知觉的横断面研究表明，与青少年相比，儿童的疼痛阈值较低。本纵向研究的目的是在纵向设计中复制这些与年龄相关的差异。共有 38 名 6 至 16 岁的儿童和青少年（每年 2 名女孩和 2 名男孩）参与了这项研究。根据德国神经性疼痛研究网络 (DFNS) 的协议，定量感觉测试 (QST) 被评估两次，间隔为 15.8 +/- 3.0 个月。 Bland-Altman 分析描述了测量的短期可靠性。使用配对 t 检验测量个体内感觉发育，并通过两次测量之间的效应大小 Cohen's d 进行量化。 QST 参数表现出良好的短期可靠性。经过一年的时间，儿童对疼痛刺激的敏感度降低，尤其是冷痛、压痛和机械痛。没有观察到对其他体感刺激的系统性发育变化。 QST 在较短的重新测试间隔内是可靠的。与之前的横断面研究结果一致，我们发现 6 至 16 岁儿童的疼痛敏感性随着年龄的增长而降低，但非伤害性体感处理在 1 年内没有差异。总而言之，这些结果凸显了对单个 QST 数据进行基于参考的解释的重要性。
Cross-sectional studies on somatosensory perception in children demonstrate lower pain thresholds for children compared with adolescents. The aim of the present longitudinal study was to replicate these age-related differences in a longitudinal design. Total 38 children and adolescents aged 6 to 16 years (two girls and two boys within each year) participated in this study. Quantitative sensory testing (QST) according to the protocol of the German research network on neuropathic pain (DFNS) was assessed twice with an interval of 15.8 +/- 3.0 months. Bland-Altman analyses describe the short-term reliability of the measurements. Intraindividual sensory development was measured using paired t-test and quantified by effect sizes Cohen's d between the two measurements. QST parameters showed good short-term reliability. Over a period of 1 year, children became less sensitive to painful stimuli, especially to cold pain, pressure pain, and mechanical pain. No systematic developmental changes were observed in response to the other somatosensory stimuli. QST is reliable over short retest intervals. In line with previous results from cross-sectional studies, we find a decrease in pain sensitivity with increasing age but no differences in nonnociceptive somatosensory processing over a period of 1 year in children between 6 and 16 years of age. Taken together, these results highlight the importance of a reference-based interpretation of the individual QST data.