Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.

Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.
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胃肠道发育、运动和炎症的血清素能控制。

DOI:
10.1002/cphy.c220024
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发表时间:
2023-06-26
影响因子:
5.8
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
作者:

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虽然它是最有名的作用,在中枢神经系统(CNS)的功能,绝大多数的血清素,或5-羟色胺(5-HT),是在胃肠道(GI)道。5-HT主要由GI上皮的肠嗜铬(EC)细胞合成,小部分由肠神经系统(ENS)的神经元合成。胃肠道含有广泛分布的5-HT受体,其参与诸如运动、感觉、炎症和神经发生的功能。5-HT在这些功能中的作用,以及其在肠-脑相互作用(DGBIs)和炎症性肠病(IBD)的病理生理学中的作用进行了综述。
Although it is most well-known for its roles in central nervous system (CNS) function, the vast majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) tract. 5-HT is synthesized mostly by enterochromaffin (EC) cells of the GI epithelium and, in small part, by neurons of the enteric nervous system (ENS). The GI tract contains an array of broadly distributed 5-HT receptors, which participate in functions such as motility, sensation, inflammation, and neurogenesis. The roles of 5-HT in these functions are reviewed, as well as its role in the pathophysiology of disorders of gut-brain interaction (DGBIs) and inflammatory bowel diseases (IBD).
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